@misc{oai:repo.qst.go.jp:00069928,
 author = {Hirayama, Ryoichi and Uzawa, Akiko and Matsumoto, Yoshitaka and Noguchi, Miho and Kase, Yuuki and Ito, Atsushi and Okayasu, Ryuichi and Koike, Sachiko and Ando, Koichi and Furusawa, Yoshiya and 平山 亮一 and 鵜澤 玲子 and 松本 孔貴 and 加瀬 優紀 and 伊藤 敦 and 岡安 隆一 and 小池 幸子 and 古澤 佳也},
 month = {Oct},
 note = {We studied DSB induction and rejoining in the clamped and non-clamped tumors after low- and high-LET radiations. SCCVII cells were transplanted into the right hind legs of C3H male mice. Conditioning irradiation with either 80 keV/μm carbon ions or 200 kVp X rays was delivered to the tumors at 5 mm diameter. Hypoxic cells were produced by clamping tumor-bearing mice 15min before irradiation in situ. Immediately after and 1 hr after irradiation, tumors were excised and rapidly cooled on ice. DSB in the tumors was analyzed by a static-field gel electrophoresis, and assayed for DSB induction and rejoining. The DSB immediately after X rays under normoxic condition was higher than under hypoxic condition. These damages in both tumor conditions were rejoined 60 to 70% within 1 hr in situ. The OER of DSB after X rays was 1.68 ± 0.31, and this value was not changed by 1 hr rejoining incubation (1.40 ± 0.26). On the other hand, no difference between X rays and carbon ions was found for the induction and rejoining of DSB. The rejoined fraction and the OER of DSB after carbon ions were similar to that after X rays. Additionally, the RBE of DSB immediately after and 1 hr after irradiation, these values were 0.9 to 1.3, and were not dependent on gases conditions. The yields of DSB induced by X rays in vivo might be similar to that after carbon ions, because the OER and RBE were not found a major difference., MICROS 2009 15th International Symposium on Microdosimetry},
 title = {INDUCTION OF DNA DSB AND ITS REJOINING IN THE CLAMPED AND NON-CLAMPED TUMORS AFTER CARBON ION BEAMS COMPARED WITH X RAYS},
 year = {2009}
}