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Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation.
https://repo.qst.go.jp/records/69740
https://repo.qst.go.jp/records/697405f9fb29e-9ac8-4bd0-8ac5-25ec06a260d9
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-04-17 | |||||
| タイトル | ||||||
| タイトル | Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhang, Hong
× Zhang, Hong× Wang, Yanling× Bing, Wang× Tanaka, Kaoru× Li, Ning× Zhou, Xin× 王 冰× 田中 薫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Breast cancer predisposing gene, BRCA1, is a major suppressor of chromosomal instability and its dysfunction affects multiple pathways involved in DNA damage response. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, is responsible for the synthesis and maintenance of the telomeric repeats at the distal ends of human chromosomes. Telomerase expression is repressed in normal human cells and activated in immortal cells and during tumorigenesis. However, the mechanism by which telomerase expression is regulated is not fully understood. There is increasing evidence that the mechanisms involved in maintenance of telomeres, specialized structures at chromosome ends, are linked with DNA damage response. We therefore investigated whether BRCA1 function affects telomere maintenance. We found that irradiation, particularly carbon ion irradiation, resulted in an increase in mRNA levels of BRCA1 and a decrease in mRNA levels of hTERT, accordingly, telomerase activity was significantly repressed. The data suggested that the hTERT inhibition was due, in part, to the increase of BRCA1 expression. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成20年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-04-14 | |||||
| 日付タイプ | Issued | |||||
