{"created":"2023-05-15T14:51:01.030633+00:00","id":69740,"links":{},"metadata":{"_buckets":{"deposit":"f5e22f49-94f0-4595-a190-f1f9bf85efd1"},"_deposit":{"created_by":1,"id":"69740","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69740"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069740","sets":["10:28"]},"author_link":["684685","684678","684681","684679","684682","684684","684680","684683"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-04-14","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Breast cancer predisposing gene, BRCA1, is a major suppressor of\nchromosomal instability and its dysfunction affects multiple pathways\ninvolved in DNA damage response. Human telomerase reverse transcriptase\n(hTERT), the catalytic subunit of human telomerase, is responsible for the\nsynthesis and maintenance of the telomeric repeats at the distal ends of\nhuman chromosomes. Telomerase expression is repressed in normal human cells\nand activated in immortal cells and during tumorigenesis. However, the\nmechanism by which telomerase expression is regulated is not fully\nunderstood. There is increasing evidence that the mechanisms involved in\nmaintenance of telomeres, specialized structures at chromosome ends, are\nlinked with DNA damage response. We therefore investigated whether BRCA1\nfunction affects telomere maintenance. We found that irradiation,\nparticularly carbon ion irradiation, resulted in an increase in mRNA levels\nof BRCA1 and a decrease in mRNA levels of hTERT, accordingly, telomerase\nactivity was significantly repressed. The data suggested that the hTERT\ninhibition was due, in part, to the increase of BRCA1 expression.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"平成20年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Hong"}],"nameIdentifiers":[{"nameIdentifier":"684678","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Yanling"}],"nameIdentifiers":[{"nameIdentifier":"684679","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"684680","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"684681","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Ning"}],"nameIdentifiers":[{"nameIdentifier":"684682","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhou, Xin"}],"nameIdentifiers":[{"nameIdentifier":"684683","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"684684","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"684685","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-17"},"publish_date":"2009-04-17","publish_status":"0","recid":"69740","relation_version_is_last":true,"title":["Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:10:58.014513+00:00"}