@misc{oai:repo.qst.go.jp:00069740,
 author = {Zhang, Hong and Wang, Yanling and Bing, Wang and Tanaka, Kaoru and Li, Ning and Zhou, Xin and 王 冰 and 田中 薫},
 month = {Apr},
 note = {Breast cancer predisposing gene, BRCA1, is a major suppressor of
chromosomal instability and its dysfunction affects multiple pathways
involved in DNA damage response. Human telomerase reverse transcriptase
(hTERT), the catalytic subunit of human telomerase, is responsible for the
synthesis and maintenance of the telomeric repeats at the distal ends of
human chromosomes. Telomerase expression is repressed in normal human cells
and activated in immortal cells and during tumorigenesis. However, the
mechanism by which telomerase expression is regulated is not fully
understood. There is increasing evidence that the mechanisms involved in
maintenance of telomeres, specialized structures at chromosome ends, are
linked with DNA damage response. We therefore investigated whether BRCA1
function affects telomere maintenance. We found that irradiation,
particularly carbon ion irradiation, resulted in an increase in mRNA levels
of BRCA1 and a decrease in mRNA levels of hTERT, accordingly, telomerase
activity was significantly repressed. The data suggested that the hTERT
inhibition was due, in part, to the increase of BRCA1 expression., 平成20年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究発表会},
 title = {Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation.},
 year = {2009}
}