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Exploring molecular targets for mesothelioma imaging
https://repo.qst.go.jp/records/69459
https://repo.qst.go.jp/records/6945970307028-2110-462a-a4cd-bafef78b5027
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-18 | |||||
| タイトル | ||||||
| タイトル | Exploring molecular targets for mesothelioma imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koshikawa, Michiko
× Koshikawa, Michiko× Hasegawa, Sumitaka× Takahashi, Isao× Hachiya, Misao× Furukawa, Takako× Akashi, Makoto× Yoshida, Satoshi× Aoki, Ichio× Saga, Tsuneo× 越川 道子× 長谷川 純崇× 高橋 功× 蜂谷 みさを× 古川 高子× 明石 真言× 吉田 聡× 青木 伊知男× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mesothelioma is a malignant tumor originated from mesothelial cells lining the pleural and peritoneal cavity and is mainly caused by asbestos exposure. The aim of this study was to identify biochemical alternations that would be the molecular targets applicable to mesothelioma imaging. For that purpose, we focused on the status of intracellular trace elements and measured the intracellular steady-state level of biologically important trace metals such as manganese (Mn), copper (Cu), zinc (Zn) in a human mesothelial cell line (MeT-5A) and in five human mesothelioma cell lines by inductively coupled plasma-mass spectrometry (ICP-MS). Furthermore, we determined the intracellular levels of manganese-superoxide dismutase (Mn-SOD) and copper/zinc-SOD (Cu/Zn-SOD). Interestingly, all mesothelioma cells highly expressed Mn-SOD compared with MeT-5A. The cells with increased Mn-SOD activity contained higher amounts of Mn, suggesting that intracellular Mn content is positively correlated with Mn-SOD. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Society for Molecular Imaging | |||||
| 発表年月日 | ||||||
| 日付 | 2008-09-13 | |||||
| 日付タイプ | Issued | |||||
