{"created":"2023-05-15T14:50:48.796789+00:00","id":69459,"links":{},"metadata":{"_buckets":{"deposit":"5b5d63ed-02d2-4be1-8d7f-927392a124c4"},"_deposit":{"created_by":1,"id":"69459","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69459"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069459","sets":["10:28"]},"author_link":["681679","681667","681676","681666","681669","681665","681668","681680","681673","681675","681663","681674","681678","681670","681672","681671","681664","681677"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-09-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mesothelioma is a malignant tumor originated from mesothelial cells lining the pleural and peritoneal cavity and is mainly caused by asbestos exposure. The aim of this study was to identify biochemical alternations that would be the molecular targets applicable to mesothelioma imaging. For that purpose, we focused on the status of intracellular trace elements and measured the intracellular steady-state level of biologically important trace metals such as manganese (Mn), copper (Cu), zinc (Zn) in a human mesothelial cell line (MeT-5A) and in five human mesothelioma cell lines by inductively coupled plasma-mass spectrometry (ICP-MS). Furthermore, we determined the intracellular levels of manganese-superoxide dismutase (Mn-SOD) and copper/zinc-SOD (Cu/Zn-SOD). Interestingly, all mesothelioma cells highly expressed Mn-SOD compared with MeT-5A. The cells with increased Mn-SOD activity contained higher amounts of Mn, suggesting that intracellular Mn content is positively correlated with Mn-SOD.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The Society for Molecular Imaging","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koshikawa, Michiko"}],"nameIdentifiers":[{"nameIdentifier":"681663","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Sumitaka"}],"nameIdentifiers":[{"nameIdentifier":"681664","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Isao"}],"nameIdentifiers":[{"nameIdentifier":"681665","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hachiya, Misao"}],"nameIdentifiers":[{"nameIdentifier":"681666","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Takako"}],"nameIdentifiers":[{"nameIdentifier":"681667","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akashi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"681668","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"681669","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"681670","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"681671","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"越川 道子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681672","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 純崇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681673","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 功","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681674","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"蜂谷 みさを","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681675","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681676","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"明石 真言","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681677","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 聡","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681678","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681679","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681680","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Exploring molecular targets for mesothelioma imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Exploring molecular targets for mesothelioma imaging"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-09-18"},"publish_date":"2008-09-18","publish_status":"0","recid":"69459","relation_version_is_last":true,"title":["Exploring molecular targets for mesothelioma imaging"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:14:14.473992+00:00"}