@misc{oai:repo.qst.go.jp:00069459,
 author = {Koshikawa, Michiko and Hasegawa, Sumitaka and Takahashi, Isao and Hachiya, Misao and Furukawa, Takako and Akashi, Makoto and Yoshida, Satoshi and Aoki, Ichio and Saga, Tsuneo and 越川 道子 and 長谷川 純崇 and 高橋 功 and 蜂谷 みさを and 古川 高子 and 明石 真言 and 吉田 聡 and 青木 伊知男 and 佐賀 恒夫},
 month = {Sep},
 note = {Mesothelioma is a malignant tumor originated from mesothelial cells lining the pleural and peritoneal cavity and is mainly caused by asbestos exposure. The aim of this study was to identify biochemical alternations that would be the molecular targets applicable to mesothelioma imaging. For that purpose, we focused on the status of intracellular trace elements and measured the intracellular steady-state level of biologically important trace metals such as manganese (Mn), copper (Cu), zinc (Zn) in a human mesothelial cell line (MeT-5A) and in five human mesothelioma cell lines by inductively coupled plasma-mass spectrometry (ICP-MS). Furthermore, we determined the intracellular levels of manganese-superoxide dismutase (Mn-SOD) and copper/zinc-SOD (Cu/Zn-SOD). Interestingly, all mesothelioma cells highly expressed Mn-SOD compared with MeT-5A. The cells with increased Mn-SOD activity contained higher amounts of Mn, suggesting that intracellular Mn content is positively correlated with Mn-SOD., The Society for Molecular Imaging},
 title = {Exploring molecular targets for mesothelioma imaging},
 year = {2008}
}