WEKO3
アイテム
17-allylamino-17-demethoxygeldanamycin enhances the cytotoxicity of tumor cells irradiated with carbon ions
https://repo.qst.go.jp/records/69052
https://repo.qst.go.jp/records/69052b04bfd06-68ca-4a90-bb08-080b668f3fe8
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-23 | |||||
| タイトル | ||||||
| タイトル | 17-allylamino-17-demethoxygeldanamycin enhances the cytotoxicity of tumor cells irradiated with carbon ions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Noguchi, Miho
× Noguchi, Miho× Yu, Dong× Hirayama, Ryoichi× Sekine, Emiko× Ando, Koichi× Okayasu, Ryuichi× 于 冬× 平山 亮一× 関根 絵美子× 安藤 興一× 岡安 隆一 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We investigated radiosensitization effect and its mechanism of Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) in human tumor cell lines irradiated with high LET carbon ions. Human tumor cell line, DU145 derived from prostate carcinoma were incubated for 24 h in the presence of 17-AAG at concentration of 0,50 and 100nM. The cells were then irradiated with carbon ions (290MeV/u, LET70keV/mm) and several biological endpoints were compared. DU145 cells showed an increase in carbon ions-induced cell death when pre-treated with 17-AAG. Our constant field gel electrophoresis (CFGE) studies indicated that 17-AAG had almost no effect on carbon ion-induced DSB repair in DU145 cells. Equally, 17AAG did not affect induction of micronucleus. In addition, poly [ADP –ribose] polymerase cleavage did not increase in DU145 cells after exposure to 17-AAG and carbon ions. Our findings suggest that mechanisms other than inhibition of DSB repair and induction of apoptosis could be involved with the radiosensitization by 17-AAG in tumor cells irradiated with carbon ions. |
|||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
