{"created":"2023-05-15T14:50:29.605823+00:00","id":69052,"links":{},"metadata":{"_buckets":{"deposit":"1ab45016-03fb-483b-b4a5-ebff9ff1e3e0"},"_deposit":{"created_by":1,"id":"69052","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69052"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069052","sets":["10:28"]},"author_link":["677742","677735","677738","677740","677743","677733","677739","677741","677737","677734","677736"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-07-12","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated radiosensitization effect and its mechanism of Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) in human tumor cell lines irradiated with high LET carbon ions. \n   Human tumor cell line, DU145 derived from prostate  carcinoma were incubated for 24 h in the presence of 17-AAG at concentration of 0,50 and 100nM. The cells were then irradiated with carbon ions (290MeV/u, LET70keV/mm) and several biological endpoints were compared. \n   DU145 cells showed an increase in carbon ions-induced cell death when pre-treated with 17-AAG.  Our constant field gel electrophoresis  (CFGE) studies indicated that 17-AAG had almost no effect on carbon ion-induced DSB repair in DU145 cells. Equally, 17AAG did not affect induction of micronucleus. In addition, poly [ADP –ribose] polymerase cleavage did not increase in DU145 cells after exposure to 17-AAG and carbon ions. Our findings suggest that mechanisms other than inhibition of DSB repair and induction of apoptosis could be involved with the radiosensitization by 17-AAG in tumor cells irradiated with carbon ions.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"13th International Congress of Radiation Research","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Noguchi, Miho"}],"nameIdentifiers":[{"nameIdentifier":"677733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yu, Dong"}],"nameIdentifiers":[{"nameIdentifier":"677734","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirayama, Ryoichi"}],"nameIdentifiers":[{"nameIdentifier":"677735","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sekine, Emiko"}],"nameIdentifiers":[{"nameIdentifier":"677736","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"677737","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"677738","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"于 冬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677739","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677740","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根 絵美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677741","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677742","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677743","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"17-allylamino-17-demethoxygeldanamycin enhances the cytotoxicity of tumor cells irradiated with carbon ions","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"17-allylamino-17-demethoxygeldanamycin enhances the cytotoxicity of tumor cells irradiated with carbon ions"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-07-23"},"publish_date":"2007-07-23","publish_status":"0","recid":"69052","relation_version_is_last":true,"title":["17-allylamino-17-demethoxygeldanamycin enhances the cytotoxicity of tumor cells irradiated with carbon ions"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:19:03.061682+00:00"}