@misc{oai:repo.qst.go.jp:00069052,
 author = {Noguchi, Miho and Yu, Dong and Hirayama, Ryoichi and Sekine, Emiko and Ando, Koichi and Okayasu, Ryuichi and 于 冬 and 平山 亮一 and 関根 絵美子 and 安藤 興一 and 岡安 隆一},
 month = {Jul},
 note = {We investigated radiosensitization effect and its mechanism of Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) in human tumor cell lines irradiated with high LET carbon ions. 
   Human tumor cell line, DU145 derived from prostate  carcinoma were incubated for 24 h in the presence of 17-AAG at concentration of 0,50 and 100nM. The cells were then irradiated with carbon ions (290MeV/u, LET70keV/mm) and several biological endpoints were compared. 
   DU145 cells showed an increase in carbon ions-induced cell death when pre-treated with 17-AAG.  Our constant field gel electrophoresis  (CFGE) studies indicated that 17-AAG had almost no effect on carbon ion-induced DSB repair in DU145 cells. Equally, 17AAG did not affect induction of micronucleus. In addition, poly [ADP –ribose] polymerase cleavage did not increase in DU145 cells after exposure to 17-AAG and carbon ions. Our findings suggest that mechanisms other than inhibition of DSB repair and induction of apoptosis could be involved with the radiosensitization by 17-AAG in tumor cells irradiated with carbon ions., 13th International Congress of Radiation Research},
 title = {17-allylamino-17-demethoxygeldanamycin enhances the cytotoxicity of tumor cells irradiated with carbon ions},
 year = {2007}
}