WEKO3
アイテム
Activation of interleulin-9 receptor and downstream STAT3/5 in primary T-lymphomas in vivo in susceptible B6 and resistant C3H mouse
https://repo.qst.go.jp/records/69035
https://repo.qst.go.jp/records/6903585a0c529-35d8-4ce4-b47e-b0366a46234b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-18 | |||||
| タイトル | ||||||
| タイトル | Activation of interleulin-9 receptor and downstream STAT3/5 in primary T-lymphomas in vivo in susceptible B6 and resistant C3H mouse | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shang, Yi
× Shang, Yi× Kakinuma, Shizuko× Amasaki, Yoshiko× Nishimura, Mayumi× Kobayashi, Yoshiro× Shimada, Yoshiya× 尚 奕× 柿沼 志津子× 甘崎 佳子× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Deregulation of cytokine receptor expression and downstream signal transduction cascade play important roles in lymphoma development. It is reported that lymphoma and leukemia occasionally express both IL-9 and IL-9 receptor (IL-9R) and proliferate in response to IL-9 in vitro. In the present study, we investigated expression and biochemical characteristics of IL-9Ralpha and activation of downstream Jak-Stat signal transduction in primary T lymphoma (TL) arising in TL-prone B6 mice and resistant C3H. The results indicated that IL-9Ralpha and IL-9Ralpha protein is markedly expressed in B6 TL-cells. Three isoforms of IL-9Ralpha proteins with different glycosylation level were found in TL. The less glycosylated IL-9Ralpha was inclined to be the more phosphorylated, being an inverse relationship between glycosylation and phosphrylation. Normal thymocytes expressed the largest isoform of IL-9Ralpha only slightly. Phosphorylation of downstream Stat3 and Stat5 was also detected, but Stat1 activation was not. Overall phosphorylation of IL-9Ralpha and activation of downstream Stat3 and Stat5 was more elevated in B6 than C3H-TL, suggesting a link between IL-9R activation and radiation susceptibility to TL induction. In parallel with Stat5 phosphorylation, expression of cyclin D1 increased in B6-TL cells, while expression of Socs3, a negative regulator of Stat5, increased in C3H. These findings indicate that IL-9Ralpha and downstream Jak-Stat signal transduction were more activated in B6 than C3H TL cells, and that target genes of downstream Stat5 differed between these two strains. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
