@misc{oai:repo.qst.go.jp:00069035,
 author = {Shang, Yi and Kakinuma, Shizuko and Amasaki, Yoshiko and Nishimura, Mayumi and Kobayashi, Yoshiro and Shimada, Yoshiya and 尚 奕 and 柿沼 志津子 and 甘崎 佳子 and 西村 まゆみ and 島田 義也},
 month = {Jul},
 note = {Deregulation of cytokine receptor expression and downstream signal transduction cascade play important roles in lymphoma development.  It is reported that lymphoma and leukemia occasionally express both IL-9 and IL-9 receptor (IL-9R) and proliferate in response to IL-9 in vitro.  In the present study, we investigated expression and biochemical characteristics of IL-9Ralpha and activation of downstream Jak-Stat signal transduction in primary T lymphoma (TL) arising in TL-prone B6 mice and resistant C3H.  The results indicated that IL-9Ralpha and IL-9Ralpha protein is markedly expressed in B6 TL-cells.  Three isoforms of IL-9Ralpha proteins with different glycosylation level were found in TL.  The less glycosylated IL-9Ralpha was inclined to be the more phosphorylated, being an inverse relationship between glycosylation and phosphrylation.  Normal thymocytes expressed the largest isoform of IL-9Ralpha only slightly.  Phosphorylation of downstream Stat3 and Stat5 was also detected, but Stat1 activation was not.  Overall phosphorylation of IL-9Ralpha and activation of downstream Stat3 and Stat5 was more elevated in B6 than C3H-TL, suggesting a link between IL-9R activation and radiation susceptibility to TL induction. In parallel with Stat5 phosphorylation, expression of cyclin D1 increased in B6-TL cells, while expression of Socs3, a negative regulator of Stat5, increased in C3H.  These findings indicate that IL-9Ralpha and downstream Jak-Stat signal transduction were more activated in B6 than C3H TL cells, and that target genes of downstream Stat5 differed between these two strains., 13th International Congress of Radiation Research},
 title = {Activation of interleulin-9 receptor and downstream STAT3/5 in primary T-lymphomas in vivo in susceptible B6 and resistant C3H mouse},
 year = {2007}
}