{"created":"2023-05-15T14:50:28.858377+00:00","id":69035,"links":{},"metadata":{"_buckets":{"deposit":"1421e9ea-0a2c-4197-b634-71a9a4e2aa4e"},"_deposit":{"created_by":1,"id":"69035","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69035"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069035","sets":["10:28"]},"author_link":["677543","677548","677550","677541","677551","677542","677545","677546","677547","677549","677544"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-07-12","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Deregulation of cytokine receptor expression and downstream signal transduction cascade play important roles in lymphoma development.  It is reported that lymphoma and leukemia occasionally express both IL-9 and IL-9 receptor (IL-9R) and proliferate in response to IL-9 in vitro.  In the present study, we investigated expression and biochemical characteristics of IL-9Ralpha and activation of downstream Jak-Stat signal transduction in primary T lymphoma (TL) arising in TL-prone B6 mice and resistant C3H.  The results indicated that IL-9Ralpha and IL-9Ralpha protein is markedly expressed in B6 TL-cells.  Three isoforms of IL-9Ralpha proteins with different glycosylation level were found in TL.  The less glycosylated IL-9Ralpha was inclined to be the more phosphorylated, being an inverse relationship between glycosylation and phosphrylation.  Normal thymocytes expressed the largest isoform of IL-9Ralpha only slightly.  Phosphorylation of downstream Stat3 and Stat5 was also detected, but Stat1 activation was not.  Overall phosphorylation of IL-9Ralpha and activation of downstream Stat3 and Stat5 was more elevated in B6 than C3H-TL, suggesting a link between IL-9R activation and radiation susceptibility to TL induction. In parallel with Stat5 phosphorylation, expression of cyclin D1 increased in B6-TL cells, while expression of Socs3, a negative regulator of Stat5, increased in C3H.  These findings indicate that IL-9Ralpha and downstream Jak-Stat signal transduction were more activated in B6 than C3H TL cells, and that target genes of downstream Stat5 differed between these two strains.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"13th International Congress of Radiation Research","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shang, Yi"}],"nameIdentifiers":[{"nameIdentifier":"677541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"677542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Amasaki, Yoshiko"}],"nameIdentifiers":[{"nameIdentifier":"677543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"677544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Yoshiro"}],"nameIdentifiers":[{"nameIdentifier":"677545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"677546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚 奕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甘崎 佳子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677551","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Activation of interleulin-9 receptor and downstream STAT3/5 in primary T-lymphomas in vivo in susceptible B6 and resistant C3H mouse","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activation of interleulin-9 receptor and downstream STAT3/5 in primary T-lymphomas in vivo in susceptible B6 and resistant C3H mouse"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-07-18"},"publish_date":"2007-07-18","publish_status":"0","recid":"69035","relation_version_is_last":true,"title":["Activation of interleulin-9 receptor and downstream STAT3/5 in primary T-lymphomas in vivo in susceptible B6 and resistant C3H mouse"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:19:15.459366+00:00"}