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Radioprotection of lactoferrin in sub-lethally X-ray irradiated mice
https://repo.qst.go.jp/records/69028
https://repo.qst.go.jp/records/690280594772e-f6f9-418e-bfe6-045fd7b6b328
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-17 | |||||
| タイトル | ||||||
| タイトル | Radioprotection of lactoferrin in sub-lethally X-ray irradiated mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nishimura, Yoshikazu
× Nishimura, Yoshikazu× Takeda, Shino× Kakuta, Izuru× Kim, Heesun× Nyuui, Minako× Ikota, Nobuo× 西村 義一× 武田 志乃× 角田 出× 乳井 美奈子× 伊古田 暢夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Lactoferrin is an iron-binding glycoprotein with a molecular weight of about 80,000. Lactoferrin was originally isolated bovine milk and found in excretions of mammals and is released from neutrophil granules during inflammation. Lactoferrin is considered a multifunctional protein. In this study, we observed the radioprotective effect of lactoferrin in mice following whole-body X-ray irradiation. (1) C3H/He mice were used in this experiment. The mice were separated tow groups One group (25 mice) were fed an AIN-93 diet, which contained 0.1 % w/w lactoferrin. The other group (25 mice) was fed an AIN-93 diet and water ad libitum. The mice were kept for 30 days on each diet, and were then exposed 6.8 Gy of whole-body irradiation. The survival rates of these mice were observed within 30 days after irradiation. The survival rate of lactoferrin-diet mice were about 23% higher than those of mice on a standard diet, and the rates dropped sharply to a plateau at day 10 after X-ray irradiation. The scavenging abilities of lactoferrin were evaluated by the ESR spin-trapping method. Lactoferrin is a radical scavenger of hydroxyl radicals and the observations suggested that radical trapping or scavenging might cause the biological response. (2) 52 of C3H/He mice were exposed 6.8 Gy of X-ray irradiation. After the irradiation, LF (4 mg) was administered 26 of mice intraperitonealy and survival rates of these mice were observed within 30 days. The survival rates of lactoferrin-treated mice and non-treated mice were 93 % and 50 %, respectively within 30 days after X-ray irradiation. The radio-protective effects of lactoferrin after X-ray irradiation in mice were investigated by using the micronucleated plychromatic erythrocyte test. Radiation induced apoptosis in mice given a single intraperitoneal injection of lactoferrin after X-ray irradiation was observed by hematoxylin-eosin staining. Lactoferrin inhibited splenocytes apoptosis and damage on a bone marrow cell after X-ray irradiation. These results suggest that lactoferrin can be used as a drug of radiation protective agent. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Radiation Research Society | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-13 | |||||
| 日付タイプ | Issued | |||||
