{"created":"2023-05-15T14:50:28.554188+00:00","id":69028,"links":{},"metadata":{"_buckets":{"deposit":"1c45e9ee-6c8d-4fe8-aa96-95d94fc5eeb5"},"_deposit":{"created_by":1,"id":"69028","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69028"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069028","sets":["10:28"]},"author_link":["677468","677470","677461","677469","677462","677465","677467","677464","677466","677460","677463"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-07-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lactoferrin is an iron-binding glycoprotein with a molecular weight of about 80,000. Lactoferrin was originally isolated bovine milk and found in excretions of mammals and is released from neutrophil granules during inflammation. Lactoferrin is considered a multifunctional protein. In this study, we observed the radioprotective effect of lactoferrin in mice following whole-body X-ray irradiation. (1) C3H/He mice were used in this experiment. The mice were separated tow groups One group (25 mice) were fed an AIN-93 diet, which contained 0.1 % w/w lactoferrin. The other group (25 mice) was fed an AIN-93 diet and water ad libitum. The mice were kept for 30 days on each diet, and were then exposed 6.8 Gy of whole-body irradiation. The survival rates of these mice were observed within 30 days after irradiation. The survival rate of lactoferrin-diet mice were about 23% higher than those of mice on a standard diet, and the rates dropped sharply to a plateau at day 10 after X-ray irradiation. The scavenging abilities of lactoferrin were evaluated by the ESR spin-trapping method. Lactoferrin is a radical scavenger of hydroxyl radicals and the observations suggested that radical trapping or scavenging might cause the biological response. (2) 52 of C3H/He mice were exposed 6.8 Gy of X-ray irradiation. After the irradiation, LF (4 mg) was administered 26 of mice intraperitonealy and survival rates of these mice were observed within 30 days. The survival rates of lactoferrin-treated mice and non-treated mice were 93 % and 50 %, respectively within 30 days after X-ray irradiation. The radio-protective effects of lactoferrin after X-ray irradiation in mice were investigated by using the micronucleated plychromatic erythrocyte test.  Radiation induced apoptosis in mice given a single intraperitoneal injection of lactoferrin after X-ray irradiation was observed by hematoxylin-eosin staining. Lactoferrin inhibited splenocytes apoptosis and damage on a bone marrow cell after X-ray irradiation. These results suggest that lactoferrin can be used as a drug of radiation protective agent.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Radiation Research Society","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishimura, Yoshikazu"}],"nameIdentifiers":[{"nameIdentifier":"677460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeda, Shino"}],"nameIdentifiers":[{"nameIdentifier":"677461","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakuta, Izuru"}],"nameIdentifiers":[{"nameIdentifier":"677462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kim, Heesun"}],"nameIdentifiers":[{"nameIdentifier":"677463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nyuui, Minako"}],"nameIdentifiers":[{"nameIdentifier":"677464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikota, Nobuo"}],"nameIdentifiers":[{"nameIdentifier":"677465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 義一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武田 志乃","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"角田 出","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677468","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"乳井 美奈子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊古田 暢夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677470","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Radioprotection of lactoferrin in sub-lethally X-ray irradiated mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radioprotection of lactoferrin in sub-lethally X-ray irradiated mice"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-07-17"},"publish_date":"2007-07-17","publish_status":"0","recid":"69028","relation_version_is_last":true,"title":["Radioprotection of lactoferrin in sub-lethally X-ray irradiated mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:19:20.810834+00:00"}