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Risk estimation of radiation-induced normal tissue injury on cancer patients by convenient analysis of marker SNPs
https://repo.qst.go.jp/records/68619
https://repo.qst.go.jp/records/686196fc4b4cf-efff-4333-94cf-6d94e7e93d00
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-08-07 | |||||
| タイトル | ||||||
| タイトル | Risk estimation of radiation-induced normal tissue injury on cancer patients by convenient analysis of marker SNPs | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Michikawa, Yuichi
× Michikawa, Yuichi× Ishikawa, Atsuko× Noda, Shuhei× Suga, Tomo× Ootsuka, Yoshimi× Kawai, Seiko× Sugahara, Keisuke× Iwakawa, Mayumi× Imai, Takashi× 道川 祐市× 石川 敦子× 野田 秀平× 菅 智× 荘司 好美× 川井 聖子× 菅原 圭亮× 岩川 眞由美× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It has been increasingly recognized that cancer patient's genetic information significantly influences therapeutic outcomes. In this study, a novel experimental system was developed for estimating risk of radiation-induced normal tissue injury on individual cancer patients based on analysis of marker SNP genotypes, which had been screened by a large association study on genes involved in DNA damage repair, cell cycle control, redox regulation, inflammation and so on. These marker SNPs were analyzed simultaneously using patient's blood-derived genomic DNA by a novel DNA chip method that provided optical detection of typing results. The resulting spot images on the DNA chips were captured by a digital camera and processed by computerized tool to call genotype of SNPs. The genotype information was then referred a database made by the foregoing large association study to statistically calculate risk of radiation-induced normal tissue injury. This system does not require specific instruments and can be easily operated in a short time. It is suitable to be used at laboratory of clinical hospitals. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Cancer Models & Mechanisms | |||||
| 発表年月日 | ||||||
| 日付 | 2006-08-04 | |||||
| 日付タイプ | Issued | |||||
