@misc{oai:repo.qst.go.jp:00068619,
 author = {Michikawa, Yuichi and Ishikawa, Atsuko and Noda, Shuhei and Suga, Tomo and Ootsuka, Yoshimi and Kawai, Seiko and Sugahara, Keisuke and Iwakawa, Mayumi and Imai, Takashi and 道川 祐市 and 石川 敦子 and 野田 秀平 and 菅 智 and 荘司 好美 and 川井 聖子 and 菅原 圭亮 and 岩川 眞由美 and 今井 高志},
 month = {Aug},
 note = {It has been increasingly recognized that cancer patient's genetic information significantly influences therapeutic outcomes.  In this study, a novel experimental system was developed for estimating risk of radiation-induced normal tissue injury on individual cancer patients based on analysis of marker SNP genotypes, which had been screened by a large association study on genes involved in DNA damage repair, cell cycle control, redox regulation, inflammation and so on.  These marker SNPs were analyzed simultaneously using patient's blood-derived genomic DNA by a novel DNA chip method that provided optical detection of typing results.  The resulting spot images on the DNA chips were captured by a digital camera and processed by computerized tool to call genotype of SNPs.  The genotype information was then referred a database made by the foregoing large association study to statistically calculate risk of radiation-induced normal tissue injury.  This system does not require specific instruments and can be easily operated in a short time.  It is suitable to be used at laboratory of clinical hospitals., Cancer Models & Mechanisms},
 title = {Risk estimation of radiation-induced normal tissue injury on cancer patients by convenient analysis of marker SNPs},
 year = {2006}
}