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アイテム
(-)-Epigallocatechin-3-O-Gallate (EGCG) inhibits apoptosis induced by ionizing radiation in keratinocytes.
https://repo.qst.go.jp/records/67759
https://repo.qst.go.jp/records/677592d43bc80-30f0-437f-879a-5b06a226103c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-04-05 | |||||
| タイトル | ||||||
| タイトル | (-)-Epigallocatechin-3-O-Gallate (EGCG) inhibits apoptosis induced by ionizing radiation in keratinocytes. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Park, Sang-hee
× Park, Sang-hee× 朴 相姫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Green tea is a rich source of polyphenols, and (-)-epigallocatechin-3-gallate (EGCG) is a major constituent of green tea polyphenols. We investigated the effect of EGCG on a apoptosis induced by irradiation in human keratinocytic cell line HaCaT. Irradiation by g-ray induced apoptosis with concomitant cleavage of caspase-3 and poly (ADP-ribose) polymerase. Treatment of cells with EGCG inhibited irradiation-induced apoptosis as detected by Hoechst staining and internucleosomal cleavage of DNA, and also prevented the cleavage of caspase-3 and PARP by irradiation. We also found that the treatment of cells with EGCG alone suppressed cell growth and induced apoptosis with a small portion in these cells. Our results suggest that EGCG inhibits irradiation-induced apoptosis by inactivating caspases pathway in HaCaT cells. Our study also indicates that EGCG has a dual effect on the survival of these keratinocytes. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | American Association for Cancer Research (AACR) 95th Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2004-03-31 | |||||
| 日付タイプ | Issued | |||||
