@misc{oai:repo.qst.go.jp:00067759,
 author = {Park, Sang-hee and 朴 相姫},
 month = {Mar},
 note = {Green tea is a rich source of polyphenols, and (-)-epigallocatechin-3-gallate (EGCG) is a major constituent of green tea polyphenols. We investigated the effect of EGCG on a apoptosis induced by irradiation in human keratinocytic cell line HaCaT. Irradiation by g-ray induced apoptosis with concomitant cleavage of caspase-3 and poly (ADP-ribose) polymerase. Treatment of cells with EGCG inhibited irradiation-induced apoptosis as detected by Hoechst staining and internucleosomal cleavage of DNA, and also prevented the cleavage of caspase-3 and PARP by irradiation. We also found that the treatment of cells with EGCG alone suppressed cell growth and induced apoptosis with a small portion in these cells. Our results suggest that EGCG inhibits irradiation-induced apoptosis by inactivating caspases pathway in HaCaT cells. Our study also indicates that EGCG has a dual effect on the survival of these keratinocytes., American Association for　Cancer Research (AACR) 95th Annual Meeting},
 title = {(-)-Epigallocatechin-3-O-Gallate (EGCG) inhibits apoptosis induced by ionizing radiation in keratinocytes.},
 year = {2004}
}