{"created":"2023-05-15T14:49:29.065697+00:00","id":67759,"links":{},"metadata":{"_buckets":{"deposit":"ae96a322-0703-439d-970a-a09fba58b172"},"_deposit":{"created_by":1,"id":"67759","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67759"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067759","sets":["10:28"]},"author_link":["665864","665863"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-03-31","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Green tea is a rich source of polyphenols, and (-)-epigallocatechin-3-gallate (EGCG) is a major constituent of green tea polyphenols. We investigated the effect of EGCG on a apoptosis induced by irradiation in human keratinocytic cell line HaCaT. Irradiation by g-ray induced apoptosis with concomitant cleavage of caspase-3 and poly (ADP-ribose) polymerase. Treatment of cells with EGCG inhibited irradiation-induced apoptosis as detected by Hoechst staining and internucleosomal cleavage of DNA, and also prevented the cleavage of caspase-3 and PARP by irradiation. We also found that the treatment of cells with EGCG alone suppressed cell growth and induced apoptosis with a small portion in these cells. Our results suggest that EGCG inhibits irradiation-induced apoptosis by inactivating caspases pathway in HaCaT cells. Our study also indicates that EGCG has a dual effect on the survival of these keratinocytes.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"American Association for　Cancer Research (AACR) 95th Annual Meeting","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Park, Sang-hee"}],"nameIdentifiers":[{"nameIdentifier":"665863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"朴 相姫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"665864","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"(-)-Epigallocatechin-3-O-Gallate (EGCG) inhibits apoptosis induced by ionizing radiation in keratinocytes.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"(-)-Epigallocatechin-3-O-Gallate (EGCG) inhibits apoptosis induced by ionizing radiation in keratinocytes."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-04-05"},"publish_date":"2004-04-05","publish_status":"0","recid":"67759","relation_version_is_last":true,"title":["(-)-Epigallocatechin-3-O-Gallate (EGCG) inhibits apoptosis induced by ionizing radiation in keratinocytes."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:34:02.565101+00:00"}