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アイテム
Evaluation of Relative Glycosaminoglycan Concentration of Reparative Cartilage with Magnetic Resonance Imaging After Autologous Chondrocyte Implantation
https://repo.qst.go.jp/records/67561
https://repo.qst.go.jp/records/675616287af6a-21e4-4b4e-b0ae-cf4c57fca6c0
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-10-30 | |||||
| タイトル | ||||||
| タイトル | Evaluation of Relative Glycosaminoglycan Concentration of Reparative Cartilage with Magnetic Resonance Imaging After Autologous Chondrocyte Implantation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Watanabe, Atsuya
× Watanabe, Atsuya× Ikehira, Hiroo× Obata, Takayuki× 渡辺 淳也× 池平 博夫× 小畠 隆行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | (Aim of Study) Current study is to evaluate the relative glycosaminoglycan(GAG) concentration of reparative cartilage after autologous chondrocytes implantation(ACI) with Gd-DTPA-enhanced magnetic resonance(MR) imaging. This method is based on the theory that both GAG and Gd-DTPA are negatively charged, that is, Gd-DTPA will distribute in cartilage inversely to the concentration of GAG. \n(Methods) Nine knees of nine patients, on which ACI of the femoral condyle was performed, were studied 6 to 36 month postoperatively. MR imaging was performed with a 1.5T magnet before and 2 hours after intravenous administration of Gd-DTPA. R1 relaxation rate measurements were made with an inversion recovery sequence. Concentration of Gd-DTPA in the cartilage was calculated by the difference between R1 before and after administration of Gd-DTPA. Second arthroscopy was performed 12 months postoperatively, and biopsies were taken from the center of reparative cartilage. The histology of reparative cartilage samples was compared with concentration of Gd-DTPA penetrated into the reparative cartilage. \n(Results) The concentration of Gd-DTPA in the reparative cartilage was higher than that in native cartilage, and there was significant difference (p<0.05). This represents that the concentration of GAG in reparative cartilage was lower than that in native cartilage. Of reparative cartilages obtained from 8 cases, the proportion of hyaline cartilage in one case was only 20 %. In latter case, most of the tissue filling the reparative cartilage was fibrocartilage, and the concentration of Gd-DTPA penetrated into the reparative cartilage was higher than that in the other cases. \n(Conclusion) The evalution of GAG concentration in the reparative cartilage was possible by using the Gd-DTPA-enhanced MR imaging. This method may be very useful for non-invasive evalution of the maturing prosess in transplanted cartilage and the long-term durabiliry of reparative cartilage. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | OARSI 2003 World Congress on Osteoarthritis | |||||
| 発表年月日 | ||||||
| 日付 | 2003-10-15 | |||||
| 日付タイプ | Issued | |||||
