{"created":"2023-05-15T14:49:19.987825+00:00","id":67561,"links":{},"metadata":{"_buckets":{"deposit":"96d96891-5222-4ea2-b4eb-332f4023dc6a"},"_deposit":{"created_by":1,"id":"67561","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67561"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067561","sets":["10:28"]},"author_link":["664012","664013","664009","664014","664010","664011"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2003-10-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"(Aim of Study)\nCurrent study is to evaluate the relative glycosaminoglycan(GAG) concentration of reparative cartilage after autologous chondrocytes implantation(ACI) with Gd-DTPA-enhanced magnetic resonance(MR) imaging. This method is based on the theory that both GAG and Gd-DTPA are negatively charged, that is, Gd-DTPA will distribute in cartilage inversely to the concentration of GAG.\n\\n(Methods)\nNine knees of nine patients, on which ACI of the femoral condyle was performed, were studied 6 to 36 month postoperatively. MR imaging was performed with a 1.5T magnet before and 2 hours after intravenous administration of Gd-DTPA. R1 relaxation rate measurements were made with an inversion recovery sequence. Concentration of Gd-DTPA in the cartilage was calculated by the difference between R1 before and after administration of Gd-DTPA.\nSecond arthroscopy was performed 12 months postoperatively, and biopsies were taken from the center of reparative cartilage. The histology of reparative cartilage samples was compared with concentration of Gd-DTPA penetrated into the reparative cartilage.\n\\n(Results)\nThe concentration of Gd-DTPA in the reparative cartilage was higher than that in native cartilage, and there was significant difference (p<0.05). This represents that the concentration of GAG in reparative cartilage was lower than that in native cartilage.\nOf reparative cartilages obtained from 8 cases, the proportion of hyaline cartilage in one case was only 20 %.\nIn latter case, most of the tissue filling the reparative cartilage was fibrocartilage, and the concentration of Gd-DTPA penetrated into the reparative cartilage was higher than that in the other cases.\n\\n(Conclusion)\nThe evalution of GAG concentration in the reparative cartilage was possible by using the Gd-DTPA-enhanced MR imaging. This method may be very useful for non-invasive evalution of the maturing prosess in transplanted cartilage and the long-term durabiliry of reparative cartilage. ","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"OARSI 2003 World Congress on Osteoarthritis","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Atsuya"}],"nameIdentifiers":[{"nameIdentifier":"664009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikehira, Hiroo"}],"nameIdentifiers":[{"nameIdentifier":"664010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Obata, Takayuki"}],"nameIdentifiers":[{"nameIdentifier":"664011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 淳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"664012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池平 博夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"664013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小畠 隆行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"664014","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Evaluation of Relative Glycosaminoglycan Concentration of Reparative Cartilage with Magnetic Resonance Imaging After Autologous Chondrocyte Implantation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of Relative Glycosaminoglycan Concentration of Reparative Cartilage with Magnetic Resonance Imaging After Autologous Chondrocyte Implantation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-10-30"},"publish_date":"2003-10-30","publish_status":"0","recid":"67561","relation_version_is_last":true,"title":["Evaluation of Relative Glycosaminoglycan Concentration of Reparative Cartilage with Magnetic Resonance Imaging After Autologous Chondrocyte Implantation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:36:18.528924+00:00"}