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Quantitative analysis for fatty acid amide hydrolase (FAAH) using PET with [11C]DFMC
https://repo.qst.go.jp/records/66996
https://repo.qst.go.jp/records/66996358bd334-b64a-4782-99db-6ba73a3f1ac6
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-11-21 | |||||
| タイトル | ||||||
| タイトル | Quantitative analysis for fatty acid amide hydrolase (FAAH) using PET with [11C]DFMC | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
山崎, 友照
× 山崎, 友照× 大矢, 智幸× 森, 若菜× 張, 一鼎× 脇坂, 秀克× 小川, 政直× 張, 明栄× 山崎 友照× 大矢 智幸× 森 若菜× 張 一鼎× 脇坂 秀克× 小川 政直× 張 明栄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: [11C]DFMC was previously developed as a promising PET ligand for fatty acid amide hydrolase (FAAH), a key enzyme for regulation of endocannabinoid system in the central nervous system. Here, we aimed to quantify FAAH concentrations using PET with [11C]DFMC in brain regions. Method: PET assessments with blood sampling were conducted for 90 min using rats. Kinetic analyses were performed by an irreversible two-tissue compartment model (2TCMi) and Patlak graphical analysis (PGA). Results: The highest radioactive uptake of [11C]DFMC was obtained in the cingulate cortex. The kinetic parameters (λk3 and Ki) for FAAH concentrations in the cingulate cortex were 0.56 ± 0.08 and 0.19 ± 0.02 mL/cm3/min, respectively. The Ki values based on 2TCMi in all regions were similar to that of PGA, which supports that kinetic parameters based on compartment model were concisely estimated. Conclusion: We successfully obtained in vivo mapping for regional FAAH concentrations by PET with [11C]DFMC. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第58回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2018-11-16 | |||||
| 日付タイプ | Issued | |||||
