@misc{oai:repo.qst.go.jp:00066996,
 author = {山崎, 友照 and 大矢, 智幸 and 森, 若菜 and 張, 一鼎 and 脇坂, 秀克 and 小川, 政直 and 張, 明栄 and 山崎 友照 and 大矢 智幸 and 森 若菜 and 張 一鼎 and 脇坂 秀克 and 小川 政直 and 張 明栄},
 month = {Nov},
 note = {Objective: [11C]DFMC was previously developed as a promising PET ligand for fatty acid amide hydrolase (FAAH), a key enzyme for regulation of endocannabinoid system in the central nervous system. Here, we aimed to quantify FAAH concentrations using PET with [11C]DFMC in brain regions.
Method: PET assessments with blood sampling were conducted for 90 min using rats. Kinetic analyses were performed by an irreversible two-tissue compartment model (2TCMi) and Patlak graphical analysis (PGA). 
Results: The highest radioactive uptake of [11C]DFMC was obtained in the cingulate cortex. The kinetic parameters (λk3 and Ki) for FAAH concentrations in the cingulate cortex were 0.56 ± 0.08 and 0.19 ± 0.02 mL/cm3/min, respectively. The Ki values based on 2TCMi in all regions were similar to that of PGA, which supports that kinetic parameters based on compartment model were concisely estimated.  
Conclusion: We successfully obtained in vivo mapping for regional FAAH concentrations by PET with [11C]DFMC., 第58回日本核医学会学術総会},
 title = {Quantitative analysis for fatty acid amide hydrolase (FAAH) using PET with [11C]DFMC},
 year = {2018}
}