{"created":"2023-05-15T14:48:54.478115+00:00","id":66996,"links":{},"metadata":{"_buckets":{"deposit":"9bd8f288-6b51-4282-a58a-92304fdab1e3"},"_deposit":{"created_by":1,"id":"66996","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66996"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066996","sets":["10:29"]},"author_link":["658579","658583","658586","658582","658577","658589","658590","658578","658587","658580","658585","658584","658588","658581"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-11-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: [11C]DFMC was previously developed as a promising PET ligand for fatty acid amide hydrolase (FAAH), a key enzyme for regulation of endocannabinoid system in the central nervous system. Here, we aimed to quantify FAAH concentrations using PET with [11C]DFMC in brain regions.\nMethod: PET assessments with blood sampling were conducted for 90 min using rats. Kinetic analyses were performed by an irreversible two-tissue compartment model (2TCMi) and Patlak graphical analysis (PGA). \nResults: The highest radioactive uptake of [11C]DFMC was obtained in the cingulate cortex. The kinetic parameters (λk3 and Ki) for FAAH concentrations in the cingulate cortex were 0.56 ± 0.08 and 0.19 ± 0.02 mL/cm3/min, respectively. The Ki values based on 2TCMi in all regions were similar to that of PGA, which supports that kinetic parameters based on compartment model were concisely estimated.  \nConclusion: We successfully obtained in vivo mapping for regional FAAH concentrations by PET with [11C]DFMC.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第58回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"658577","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大矢, 智幸"}],"nameIdentifiers":[{"nameIdentifier":"658578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"658579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"658580","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"658581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"658582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"658583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658584","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大矢 智幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658585","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 若菜","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658587","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658588","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658589","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658590","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Quantitative analysis for fatty acid amide hydrolase (FAAH) using PET with [11C]DFMC","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Quantitative analysis for fatty acid amide hydrolase (FAAH) using PET with [11C]DFMC"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-21"},"publish_date":"2018-11-21","publish_status":"0","recid":"66996","relation_version_is_last":true,"title":["Quantitative analysis for fatty acid amide hydrolase (FAAH) using PET with [11C]DFMC"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:42:41.057913+00:00"}