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Investigating the influence of Arginine Dimethylation on Nucleosome Dynamics using All-atom Simulation and Kinetic Analysis
https://repo.qst.go.jp/records/66919
https://repo.qst.go.jp/records/6691943a9c00b-f21c-438e-8de0-11fa87a57921
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-09-19 | |||||
| タイトル | ||||||
| タイトル | Investigating the influence of Arginine Dimethylation on Nucleosome Dynamics using All-atom Simulation and Kinetic Analysis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Z., Li
× Z., Li× H., Kono× リ ツェンハイ× 河野 秀俊 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Post-translational modification (PTM) of nucleosome regulates gene activity. To study impact of a single PTM on the nucleosome structure, we performed all-atom replica-exchange molecular dynamics simulations with and without a single PTM, either symmetric (R42me2s) or asymmetric (R42me2a) dimethylation. With the aiding of comprehensive kinetics analysis, our simulations showed R42me2a nucleosome promoted the DNA opening rate and adopted a more opened conformation, but not R42me2s. This study unravels the mechanism for distinct gene-regulation induced by a subtle, different dimethylation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第56回日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2018-09-16 | |||||
| 日付タイプ | Issued | |||||
