WEKO3
アイテム
Investigating the influence of Arginine Dimethylation on Nucleosome Dynamics using All-atom Simulation and Kinetic Analysis
https://repo.qst.go.jp/records/66919
https://repo.qst.go.jp/records/6691943a9c00b-f21c-438e-8de0-11fa87a57921
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-09-19 | |||||
タイトル | ||||||
タイトル | Investigating the influence of Arginine Dimethylation on Nucleosome Dynamics using All-atom Simulation and Kinetic Analysis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Z., Li
× Z., Li× H., Kono× リ ツェンハイ× 河野 秀俊 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Post-translational modification (PTM) of nucleosome regulates gene activity. To study impact of a single PTM on the nucleosome structure, we performed all-atom replica-exchange molecular dynamics simulations with and without a single PTM, either symmetric (R42me2s) or asymmetric (R42me2a) dimethylation. With the aiding of comprehensive kinetics analysis, our simulations showed R42me2a nucleosome promoted the DNA opening rate and adopted a more opened conformation, but not R42me2s. This study unravels the mechanism for distinct gene-regulation induced by a subtle, different dimethylation. | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第56回日本生物物理学会年会 | |||||
発表年月日 | ||||||
日付 | 2018-09-16 | |||||
日付タイプ | Issued |