@misc{oai:repo.qst.go.jp:00066919,
 author = {Z., Li and H., Kono and リ ツェンハイ and 河野 秀俊},
 month = {Sep},
 note = {Post-translational modification (PTM) of nucleosome regulates gene activity. To study impact of a single PTM on the nucleosome structure, we performed all-atom replica-exchange molecular dynamics simulations with and without a single PTM, either symmetric (R42me2s) or asymmetric (R42me2a) dimethylation. With the aiding of comprehensive kinetics analysis, our simulations showed R42me2a nucleosome promoted the DNA opening rate and adopted a more opened conformation, but not R42me2s. This study unravels the mechanism for distinct gene-regulation induced by a subtle, different dimethylation., 第56回日本生物物理学会年会},
 title = {Investigating the influence of Arginine Dimethylation on Nucleosome Dynamics using All-atom Simulation and Kinetic Analysis},
 year = {2018}
}