{"created":"2023-05-15T14:48:51.215192+00:00","id":66919,"links":{},"metadata":{"_buckets":{"deposit":"ddf843e1-f03e-42e0-9d0e-722761ffc37b"},"_deposit":{"created_by":1,"id":"66919","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66919"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066919","sets":["10:29"]},"author_link":["657872","657870","657871","657869"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-09-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Post-translational modification (PTM) of nucleosome regulates gene activity. To study impact of a single PTM on the nucleosome structure, we performed all-atom replica-exchange molecular dynamics simulations with and without a single PTM, either symmetric (R42me2s) or asymmetric (R42me2a) dimethylation. With the aiding of comprehensive kinetics analysis, our simulations showed R42me2a nucleosome promoted the DNA opening rate and adopted a more opened conformation, but not R42me2s. This study unravels the mechanism for distinct gene-regulation induced by a subtle, different dimethylation.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第56回日本生物物理学会年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Z., Li"}],"nameIdentifiers":[{"nameIdentifier":"657869","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"H., Kono"}],"nameIdentifiers":[{"nameIdentifier":"657870","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"リ ツェンハイ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657871","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河野 秀俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657872","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Investigating the influence of Arginine Dimethylation on Nucleosome Dynamics using All-atom Simulation and Kinetic Analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Investigating the influence of Arginine Dimethylation on Nucleosome Dynamics using All-atom Simulation and Kinetic Analysis"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-09-19"},"publish_date":"2018-09-19","publish_status":"0","recid":"66919","relation_version_is_last":true,"title":["Investigating the influence of Arginine Dimethylation on Nucleosome Dynamics using All-atom Simulation and Kinetic Analysis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:43:29.292044+00:00"}