{"_buckets": {"deposit": "a8374285-49ad-4faf-b1dd-3d1cad1e89c5"}, "_deposit": {"created_by": 1, "id": "66053", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "66053"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00066053", "sets": ["29"]}, "author_link": ["650406", "650405", "650411", "650412", "650408", "650413", "650403", "650410", "650418", "650421", "650409", "650415", "650420", "650416", "650402", "650419", "650417", "650407", "650414", "650404"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2016-11-05", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "セロトニンは摂食と体重に関連し、セロトニントランスポーター（SERT）の阻害により摂食を抑制できることが示され、SERT選択的PETプローブを用いて肥満の評価研究が行われている。イミダゾリンI\u003cSUB\u003e2\u003c/SUB\u003e受容体（I\u003cSUB\u003e2\u003c/SUB\u003eR）は、摂食中枢である視床下部に多く存在しており、I\u003cSUB\u003e2\u003c/SUB\u003eR選択的PETプローブにより肥満を評価できる可能性がある。本研究では、SERT選択的PETプローブ [\u003cSUP\u003e11\u003c/SUP\u003eC]DASB及びI\u003cSUB\u003e2\u003c/SUB\u003eR選択的PETプローブ[\u003cSUP\u003e11\u003c/SUP\u003eC]BU99008によるやせ型ラット（Zucker-Lean）及び肥満型ラット（Zucker-Fatty）用いた脳PET定量測定を行った。その結果、ラット脳視床下部において、SERTに対する[\u003cSUP\u003e11\u003c/SUP\u003eC]DASBの結合はやせ型に比べて肥満型が1.6倍程度増加し、また、I\u003cSUB\u003e2\u003c/SUB\u003eR に対する[\u003cSUP\u003e11\u003c/SUP\u003eC]BU99008の結合は1.9倍程度増加した。[\u003cSUP\u003e11\u003c/SUP\u003eC]DASB及び[\u003cSUP\u003e11\u003c/SUP\u003eC]BU99008用いたPET測定により肥満を評価できると考えられ、抗肥満薬を評価する手法として期待される。", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要（会議名, 開催地, 会期, 主催者等）", "attribute_value_mlt": [{"subitem_description": " 第56回日本核医学会学術総会", "subitem_description_type": 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