{"created":"2023-05-15T14:48:12.065163+00:00","id":66053,"links":{},"metadata":{"_buckets":{"deposit":"a8374285-49ad-4faf-b1dd-3d1cad1e89c5"},"_deposit":{"created_by":1,"id":"66053","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66053"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066053","sets":["10:29"]},"author_link":["650406","650405","650411","650412","650408","650413","650403","650410","650418","650421","650409","650415","650420","650416","650402","650419","650417","650407","650414","650404"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"セロトニンは摂食と体重に関連し、セロトニントランスポーター（SERT）の阻害により摂食を抑制できることが示され、SERT選択的PETプローブを用いて肥満の評価研究が行われている。イミダゾリンI<SUB>2</SUB>受容体（I<SUB>2</SUB>R）は、摂食中枢である視床下部に多く存在しており、I<SUB>2</SUB>R選択的PETプローブにより肥満を評価できる可能性がある。本研究では、SERT選択的PETプローブ [<SUP>11</SUP>C]DASB及びI<SUB>2</SUB>R選択的PETプローブ[<SUP>11</SUP>C]BU99008によるやせ型ラット（Zucker-Lean）及び肥満型ラット（Zucker-Fatty）用いた脳PET定量測定を行った。その結果、ラット脳視床下部において、SERTに対する[<SUP>11</SUP>C]DASBの結合はやせ型に比べて肥満型が1.6倍程度増加し、また、I<SUB>2</SUB>R に対する[<SUP>11</SUP>C]BU99008の結合は1.9倍程度増加した。[<SUP>11</SUP>C]DASB及び[<SUP>11</SUP>C]BU99008用いたPET測定により肥満を評価できると考えられ、抗肥満薬を評価する手法として期待される。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":" 第56回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河村, 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秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"650417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"650418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"650419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"650420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"650421","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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