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Tau deposition estimated by [11C]PBB3 PET in Alzheimer’s disease, MCI with and without amyloid deposition, and cognitive healthy subjects
https://repo.qst.go.jp/records/65627
https://repo.qst.go.jp/records/65627a8106593-13d5-4375-8107-d957993c47fb
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-20 | |||||
| タイトル | ||||||
| タイトル | Tau deposition estimated by [11C]PBB3 PET in Alzheimer’s disease, MCI with and without amyloid deposition, and cognitive healthy subjects | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shimada, Hitoshi
× Shimada, Hitoshi× Higuchi, Makoto× Shinotoh, Hitoshi× Furukawa, Shogo× Eguchi, Yoko× Takahata, Keisuke× Kodaka, Fumitoshi× Kimura, Yasuyuki× Yamada, Makiko× Sahara, Naruhiko× Maruyama, Masahiro× Takano, Harumasa× Zhang, Ming-Rong× Ito, Hiroshi× Suhara, Tetsuya× 島田 斉× 樋口 真人× 篠遠 仁× 古川 彰吾× 江口 洋子× 高畑 圭輔× 小高 文聰× 木村 泰之× 山田 真希子× 佐原 成彦× 丸山 将浩× 高野 晴成× 張 明栄× 伊藤 浩× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background and aims: [11C]PBB3 is a novel tau imaging PET ligand, showing high affinity and selectivity for tau deposits. Our preliminary clinical data suggested [11C]PBB3 binding could reflect the dementia severity in AD patients. The aim of the present study was to investigate characteristics of [11C]PBB3 binding and its relation with clinical aspects in cognitively healthy subjects and patients with cognitive impairments. Methods: Participants were 14 AD patients, 13 mild cognitive impairments (MCI) patients and 22 healthy controls (HCs). We performed [11C]PBB3 PET as well as [11C]PIB PET. Standardized uptake value ratio (SUVR) was calculated for each PET image using the cerebellar cortex as reference region. Three-dimensional T1-weighted MRI was also acquired, and brain atrophy was also assessed using voxel-based morphometry technique. Results: All HCs were PIB-negative, and all AD patients and 7 of 13 MCI patients were PIB-positive. [11C]PBB3 was highly accumulated in the medial temporal cortex of all AD and PIB-positive MCI patients, in which binding of [11C]PIB was minimal. Distribution of [11C]PBB3 accumulation observed in AD and PIB-positive MCI patients extended to the entire limbic system and subsequently to the neocortex as a function of the disease severity. Mean cortical [11C]PBB3 binding showed significantly positive correlation with dementia severity assessed with clinical dementia rating scale (CDR) sum of boxes among AD and PIB-positive MCI patients (r = 0.67, p = 0.02; adjusted by age and educational background). Some PIB-negative MCI patients and HCs showed noticeable accumulation of [11C] PBB3. Interestingly, one PIB-negative MCI patients showed asymmetrical cortical atrophy around ambient gyrus resembling argyrophilic grain dementia (AGD), a sporadic 4-repeat tauopathy, accompanying high uptake of [11C]PBB3. Conclusions: The present study supported the spread of [11C]PBB3 binding reflect the dementia severity in AD and MCI due to AD patients. Furthermore, [11C]PBB3 PET could enable the antemortem diagnosis of AGD. \nKeywords Tau imaging, [11C]PBB3, Alzheimer’s disease, mild cognitive impairment, argyrophilic grain dementia |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Human Amyloid Imaging Conference (HAI) 2014 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-01-16 | |||||
| 日付タイプ | Issued | |||||
