{"created":"2023-05-15T14:47:52.411529+00:00","id":65627,"links":{},"metadata":{"_buckets":{"deposit":"9447f7c6-d0f0-4dec-a1d5-151825532b48"},"_deposit":{"created_by":1,"id":"65627","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65627"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065627","sets":["10:29"]},"author_link":["646404","646413","646402","646410","646414","646397","646399","646411","646412","646398","646392","646406","646387","646388","646385","646393","646389","646390","646395","646409","646403","646391","646400","646386","646407","646394","646408","646405","646396","646401"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-01-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and aims:\n[11C]PBB3 is a novel tau imaging PET ligand, showing high affinity and selectivity for tau deposits. Our preliminary clinical data suggested [11C]PBB3 binding could reflect the dementia severity in AD patients. The aim of the present study was to investigate characteristics of [11C]PBB3 binding and its relation with clinical aspects in cognitively healthy subjects and patients with cognitive impairments.\nMethods:\nParticipants were 14 AD patients, 13 mild cognitive impairments (MCI) patients and 22 healthy controls (HCs). We performed [11C]PBB3 PET as well as [11C]PIB PET. Standardized uptake value ratio (SUVR) was calculated for each PET image using the cerebellar cortex as reference region. Three-dimensional T1-weighted MRI was also acquired, and brain atrophy was also assessed using voxel-based morphometry technique.\nResults:\nAll HCs were PIB-negative, and all AD patients and 7 of 13 MCI patients were PIB-positive. [11C]PBB3 was highly accumulated in the medial temporal cortex of all AD and PIB-positive MCI patients, in which binding of [11C]PIB was minimal. Distribution of [11C]PBB3 accumulation observed in AD and PIB-positive MCI patients extended to the entire limbic system and subsequently to the neocortex as a function of the disease severity. Mean cortical [11C]PBB3 binding showed significantly positive correlation with dementia severity assessed with clinical dementia rating scale (CDR) sum of boxes among AD and PIB-positive MCI patients (r = 0.67, p = 0.02; adjusted by age and educational background). Some PIB-negative MCI patients and HCs showed noticeable accumulation of [11C] PBB3. Interestingly, one PIB-negative MCI patients showed asymmetrical cortical atrophy around ambient gyrus resembling argyrophilic grain dementia (AGD), a sporadic 4-repeat tauopathy, accompanying high uptake of [11C]PBB3.\nConclusions:\nThe present study supported the spread of [11C]PBB3 binding reflect the dementia severity in AD and MCI due to AD patients. Furthermore, [11C]PBB3 PET could enable the antemortem diagnosis of AGD.\n\\nKeywords\nTau imaging, [11C]PBB3, Alzheimer’s disease, mild cognitive impairment, argyrophilic grain dementia","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Human Amyloid Imaging Conference (HAI) 2014","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"646385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"646386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinotoh, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"646387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Shogo"}],"nameIdentifiers":[{"nameIdentifier":"646388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eguchi, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"646389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahata, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"646390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodaka, Fumitoshi"}],"nameIdentifiers":[{"nameIdentifier":"646391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"646392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Makiko"}],"nameIdentifiers":[{"nameIdentifier":"646393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko"}],"nameIdentifiers":[{"nameIdentifier":"646394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maruyama, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"646395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Harumasa"}],"nameIdentifiers":[{"nameIdentifier":"646396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"646397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"646398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"646399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 彰吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑 圭輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 真希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐原 成彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山 将浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646414","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Tau deposition estimated by [11C]PBB3 PET in Alzheimer’s disease, MCI with and without amyloid deposition, and cognitive healthy subjects","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tau deposition estimated by [11C]PBB3 PET in Alzheimer’s disease, MCI with and without amyloid deposition, and cognitive healthy subjects"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-20"},"publish_date":"2015-04-20","publish_status":"0","recid":"65627","relation_version_is_last":true,"title":["Tau deposition estimated by [11C]PBB3 PET in Alzheimer’s disease, MCI with and without amyloid deposition, and cognitive healthy subjects"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:57:59.965115+00:00"}