@misc{oai:repo.qst.go.jp:00065627,
 author = {Shimada, Hitoshi and Higuchi, Makoto and Shinotoh, Hitoshi and Furukawa, Shogo and Eguchi, Yoko and Takahata, Keisuke and Kodaka, Fumitoshi and Kimura, Yasuyuki and Yamada, Makiko and Sahara, Naruhiko and Maruyama, Masahiro and Takano, Harumasa and Zhang, Ming-Rong and Ito, Hiroshi and Suhara, Tetsuya and 島田 斉 and 樋口 真人 and 篠遠 仁 and 古川 彰吾 and 江口 洋子 and 高畑 圭輔 and 小高 文聰 and 木村 泰之 and 山田 真希子 and 佐原 成彦 and 丸山 将浩 and 高野 晴成 and 張 明栄 and 伊藤 浩 and 須原 哲也},
 month = {Jan},
 note = {Background and aims:
[11C]PBB3 is a novel tau imaging PET ligand, showing high affinity and selectivity for tau deposits. Our preliminary clinical data suggested [11C]PBB3 binding could reflect the dementia severity in AD patients. The aim of the present study was to investigate characteristics of [11C]PBB3 binding and its relation with clinical aspects in cognitively healthy subjects and patients with cognitive impairments.
Methods:
Participants were 14 AD patients, 13 mild cognitive impairments (MCI) patients and 22 healthy controls (HCs). We performed [11C]PBB3 PET as well as [11C]PIB PET. Standardized uptake value ratio (SUVR) was calculated for each PET image using the cerebellar cortex as reference region. Three-dimensional T1-weighted MRI was also acquired, and brain atrophy was also assessed using voxel-based morphometry technique.
Results:
All HCs were PIB-negative, and all AD patients and 7 of 13 MCI patients were PIB-positive. [11C]PBB3 was highly accumulated in the medial temporal cortex of all AD and PIB-positive MCI patients, in which binding of [11C]PIB was minimal. Distribution of [11C]PBB3 accumulation observed in AD and PIB-positive MCI patients extended to the entire limbic system and subsequently to the neocortex as a function of the disease severity. Mean cortical [11C]PBB3 binding showed significantly positive correlation with dementia severity assessed with clinical dementia rating scale (CDR) sum of boxes among AD and PIB-positive MCI patients (r = 0.67, p = 0.02; adjusted by age and educational background). Some PIB-negative MCI patients and HCs showed noticeable accumulation of [11C] PBB3. Interestingly, one PIB-negative MCI patients showed asymmetrical cortical atrophy around ambient gyrus resembling argyrophilic grain dementia (AGD), a sporadic 4-repeat tauopathy, accompanying high uptake of [11C]PBB3.
Conclusions:
The present study supported the spread of [11C]PBB3 binding reflect the dementia severity in AD and MCI due to AD patients. Furthermore, [11C]PBB3 PET could enable the antemortem diagnosis of AGD.
\nKeywords
Tau imaging, [11C]PBB3, Alzheimer’s disease, mild cognitive impairment, argyrophilic grain dementia, Human Amyloid Imaging Conference (HAI) 2014},
 title = {Tau deposition estimated by [11C]PBB3 PET in Alzheimer’s disease, MCI with and without amyloid deposition, and cognitive healthy subjects},
 year = {2014}
}