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Transcription factors potentially involved in gene regulation after long-term, low dose-rate irradiation
https://repo.qst.go.jp/records/64998
https://repo.qst.go.jp/records/64998271ca332-63ff-4078-a973-486ccca103b7
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-05-17 | |||||
| タイトル | ||||||
| タイトル | Transcription factors potentially involved in gene regulation after long-term, low dose-rate irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference output | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nenoi, Mitsuru
× Nenoi, Mitsuru× Vares, Guillaume× Uehara, Yoshihiko× Ono, Tetsuya× Nakajima, Tetsuo× Bing, Wang× Taki, Keiko× Matsumoto, Tsuneya× Oghiso, Yoichi× Tanaka, Kimio× Ichinohe, Kazuaki× Nakamura, Shingo× Tanaka, Satoshi× 根井 充× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 中島 徹夫× 王 冰× 瀧 景子× 松本 恒弥× 一戸 一晃 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Altered gene expression in vivo after low-dose and low -dose rate irradiation has been observed in a variety of experimental systems. However, few studies actually investigated the underlying mechanisms for these genetic responses. In this study, we used pre-existing microarray data and searched for gene modulations in response to long-term (400 days), low-dose-rate irradiation (0.05-20mGy/day). Recognition sequences for transcription factors (TFs) were searched in the neighboring region of the up-regulated, down-regulated, and unaffected genes. As a result, we suggested 21 potential TF-binding sites with significantly different incidence between the three gene groups. The binding sites for sterol regulatory element-binding protein 1 (SREBP-1), aryl hydrocarbon receptor (AhR/Ar) and olfactory 1 (Olf-1) were suggested to be involved in up-regulation, while the binding sites for glucocorticoid receptor (GR) and hepatocyte nuclear factor 1(HNF-1) were suggested to be involved in down-regulation of the genes. Interestingly higher dose-rate irradiation has been shown to enhance the GR activity in mice, suggesting a distinct regulation of GR activity by radiation depending on the dose-rate. As it was recently reported that an activated GR due to an elevated glucocorticoid potentially increased susceptibility to radiation tumorigenesis, a long-term low-dose-rate exposure could have a different influence on the health of individuals from that of high-dose-rate exposure through a distinct regulation of TFs including GR. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 3rd Asian Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2013-05-13 | |||||
| 日付タイプ | Issued | |||||
