@misc{oai:repo.qst.go.jp:00064998,
 author = {Nenoi, Mitsuru and Vares, Guillaume and Uehara, Yoshihiko and Ono, Tetsuya and Nakajima, Tetsuo and Bing, Wang and Taki, Keiko and Matsumoto, Tsuneya and Oghiso, Yoichi and Tanaka, Kimio and Ichinohe, Kazuaki and Nakamura, Shingo and Tanaka, Satoshi and 根井 充 and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 中島 徹夫 and 王 冰 and 瀧 景子 and 松本 恒弥 and 一戸 一晃},
 month = {May},
 note = {Altered gene expression in vivo after low-dose and low -dose rate irradiation has been observed in a variety of experimental systems. However, few studies actually investigated the underlying mechanisms for these genetic responses. In this study, we used pre-existing microarray data and searched for gene modulations in response to long-term (400 days), low-dose-rate irradiation (0.05-20mGy/day). Recognition sequences for transcription factors (TFs) were searched in the neighboring region of the up-regulated, down-regulated, and unaffected genes. As a result, we suggested 21 potential TF-binding sites with significantly different incidence between the three gene groups. The binding sites for sterol regulatory element-binding protein 1 (SREBP-1), aryl hydrocarbon receptor (AhR/Ar) and olfactory 1 (Olf-1) were suggested to be involved in up-regulation, while the binding sites for glucocorticoid receptor (GR) and hepatocyte nuclear factor 1(HNF-1) were suggested to be involved in down-regulation of the genes. Interestingly higher dose-rate irradiation has been shown to enhance the GR activity in mice, suggesting a distinct regulation of GR activity by radiation depending on the dose-rate. As it was recently reported that an activated GR due to an elevated glucocorticoid potentially increased susceptibility to radiation tumorigenesis, a long-term low-dose-rate exposure could have a different influence on the health of individuals from that of high-dose-rate exposure through a distinct regulation of TFs including GR., The 3rd Asian Congress of Radiation Research},
 title = {Transcription factors potentially involved in gene regulation after long-term, low dose-rate irradiation},
 year = {2013}
}