{"created":"2023-05-15T14:47:24.146736+00:00","id":64998,"links":{},"metadata":{"_buckets":{"deposit":"d70936de-08b4-4a2e-b11a-249d27e9335a"},"_deposit":{"created_by":1,"id":"64998","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64998"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064998","sets":["10:29"]},"author_link":["640450","640445","640454","640439","640440","640447","640448","640451","640444","640446","640441","640453","640438","640443","640452","640437","640449","640442","640435","640436"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Altered gene expression in vivo after low-dose and low -dose rate irradiation has been observed in a variety of experimental systems. However, few studies actually investigated the underlying mechanisms for these genetic responses. In this study, we used pre-existing microarray data and searched for gene modulations in response to long-term (400 days), low-dose-rate irradiation (0.05-20mGy/day). Recognition sequences for transcription factors (TFs) were searched in the neighboring region of the up-regulated, down-regulated, and unaffected genes. As a result, we suggested 21 potential TF-binding sites with significantly different incidence between the three gene groups. The binding sites for sterol regulatory element-binding protein 1 (SREBP-1), aryl hydrocarbon receptor (AhR/Ar) and olfactory 1 (Olf-1) were suggested to be involved in up-regulation, while the binding sites for glucocorticoid receptor (GR) and hepatocyte nuclear factor 1(HNF-1) were suggested to be involved in down-regulation of the genes. Interestingly higher dose-rate irradiation has been shown to enhance the GR activity in mice, suggesting a distinct regulation of GR activity by radiation depending on the dose-rate. As it was recently reported that an activated GR due to an elevated glucocorticoid potentially increased susceptibility to radiation tumorigenesis, a long-term low-dose-rate exposure could have a different influence on the health of individuals from that of high-dose-rate exposure through a distinct regulation of TFs including GR.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 3rd Asian Congress of Radiation Research","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"640435","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{"nameIdentifier":"640436","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uehara, Yoshihiko"}],"nameIdentifiers":[{"nameIdentifier":"640437","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"640438","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo"}],"nameIdentifiers":[{"nameIdentifier":"640439","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"640440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taki, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"640441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Tsuneya"}],"nameIdentifiers":[{"nameIdentifier":"640442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oghiso, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"640443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kimio"}],"nameIdentifiers":[{"nameIdentifier":"640444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichinohe, Kazuaki"}],"nameIdentifiers":[{"nameIdentifier":"640445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Shingo"}],"nameIdentifiers":[{"nameIdentifier":"640446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"640447","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640448","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640449","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 徹夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640450","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640451","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"瀧 景子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640452","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 恒弥","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"一戸 一晃","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640454","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Transcription factors potentially involved in gene regulation after long-term, low dose-rate irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Transcription factors potentially involved in gene regulation after long-term, low dose-rate irradiation"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-05-17"},"publish_date":"2013-05-17","publish_status":"0","recid":"64998","relation_version_is_last":true,"title":["Transcription factors potentially involved in gene regulation after long-term, low dose-rate irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:05:12.947254+00:00"}