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炭素イオン線治療後の放射線脳障害の予測因子に関する研究
https://repo.qst.go.jp/records/64899
https://repo.qst.go.jp/records/648999fc000a2-9619-45ab-aad7-3b5893d0dba3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-01-04 | |||||
| タイトル | ||||||
| タイトル | 炭素イオン線治療後の放射線脳障害の予測因子に関する研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
小藤, 昌志
× 小藤, 昌志× 長谷川, 安都佐× 高木, 亮× 森川, 貴迪× 神立, 進× 岸本, 理和× 神宮, 啓一× 小藤 昌志× 長谷川 安都佐× 高木 亮× 森川 貴迪× 神立 進× 岸本 理和× 神宮 啓一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: The purpose of this study is to determine the risk factors for brain injury (BI) after carbon ion radiotherapy. Materials and Methods: Thirty-eight patients with skull base tumors who were treated with carbon ion radiotherapy at a total dose of 48.0-60.8 GyE in 16 fractions were included in this study. BI on MRI was assessed according to the Late Effects of Normal Tissue-Subjective, Objective, Management, Analytic criteria. The correlations of the clinical and dosimetric parameters with the incidence of >grade 2 BI were retrospectively analyzed using MRI. Results: The median follow-up period was 67 months (range: 24-152 months). The 5-year actuarial likelihoods of >grade 2 BI were 24.1%. Dose-volume histogram analysis revealed that the percentages of brain volume receiving more than 20, 30, 40, and 50 GyE (V50 ) were significantly higher in patients with >grade 2 BI than in those with <grade 1 BI. On univariate analysis, V40 and V50 were found to be correlated with the development of >grade 2 BI. Multivariate analysis demonstrated that V50 was a significant predictor of >grade 2 BI. Conclusions: V50 was a significant risk factor for >grade 2 BI induced by carbon ion radiotherapy administered in 16 fractions. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成23年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2012-04-24 | |||||
| 日付タイプ | Issued | |||||
