@misc{oai:repo.qst.go.jp:00064899,
 author = {小藤, 昌志 and 長谷川, 安都佐 and 高木, 亮 and 森川, 貴迪 and 神立, 進 and 岸本, 理和 and 神宮, 啓一 and 小藤 昌志 and 長谷川 安都佐 and 高木 亮 and 森川 貴迪 and 神立 進 and 岸本 理和 and 神宮 啓一},
 month = {Apr},
 note = {Purpose: The purpose of this study is to determine the risk factors for brain injury (BI) after carbon ion radiotherapy.
Materials and Methods: Thirty-eight patients with skull base tumors who were treated with carbon ion radiotherapy at a total dose of 48.0-60.8  GyE in 16 fractions were included in this study. BI on MRI was assessed according to the Late Effects of Normal Tissue-Subjective, Objective, Management, Analytic criteria. The correlations of the clinical and dosimetric parameters with the incidence of >grade 2 BI were retrospectively analyzed using MRI.
Results: The median follow-up period was 67 months (range: 24-152 months). The 5-year actuarial likelihoods of >grade 2 BI were 24.1%. Dose-volume histogram analysis revealed that the percentages of brain volume receiving more than 20, 30, 40, and 50 GyE (V50 ) were significantly higher in patients with >grade 2 BI than in those with <grade 1 BI. On univariate analysis, V40 and V50 were found to be correlated with the development of >grade 2 BI. Multivariate analysis demonstrated that V50 was a significant predictor of  >grade 2 BI. 
Conclusions: V50 was a significant risk factor for >grade 2 BI induced by carbon ion radiotherapy administered in 16 fractions., 平成23年度HIMAC共同利用研究成果発表会},
 title = {炭素イオン線治療後の放射線脳障害の予測因子に関する研究},
 year = {2012}
}