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重粒子線の骨代謝におよぼす影響
https://repo.qst.go.jp/records/64104
https://repo.qst.go.jp/records/64104a01a361a-40b8-46e0-88a7-12b807b3bec6
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-11-16 | |||||
| タイトル | ||||||
| タイトル | 重粒子線の骨代謝におよぼす影響 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
澤尻, 昌彦
× 澤尻, 昌彦× 野村, 雄二× 滝波, 修一× 丸山, 耕一× 溝江, 純悦× 澤尻 昌彦× 野村 雄二× 滝波 修一× 丸山 耕一× 溝江 純悦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To examine the effects of carbon ion and gamma ray irradiation on cancer-induced osteoclastogenesis, mouse calvarias MC3T3-E1cells were cultured with conditioned medium from irradiated and non-irradiated MCF7 human breast cancer cells. We examined RANKL and OPG mRNA expression in osteoblastic MC3T3-E1 cells following treatment with conditioned MCF7 medium. Co-cultured MC3T3-E1 and bone marrow cells treated with conditioned medium from irradiated MCF7 cells showed decreased numbers of osteoclasts assessed using TRAP staining. Conditioned medium from control MCF7 cells elevated the RANKL/OPG mRNA ratio in MC3T3-E1 cells; this effect was suppressed by carbon ion irradiation of the MCF7 cells. These data demonstrate that indirect interactions between breast cancer cells and MC3T3-E1 cells induce osteoclastogenesis in vitro through modulation of RANKL expression and that this process is suppressed by carbon ion irradiation. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H21年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-04-20 | |||||
| 日付タイプ | Issued | |||||
