{"created":"2023-05-15T14:46:43.450478+00:00","id":64104,"links":{},"metadata":{"_buckets":{"deposit":"153746fc-9aac-4ace-86bf-19fb14405fd0"},"_deposit":{"created_by":1,"id":"64104","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64104"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064104","sets":["10:29"]},"author_link":["632351","632354","632359","632352","632355","632350","632358","632353","632357","632356"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-04-20","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To examine the effects of carbon ion and gamma ray irradiation on cancer-induced osteoclastogenesis, mouse calvarias MC3T3-E1cells were cultured with conditioned medium from irradiated and non-irradiated MCF7 human breast cancer cells. We examined RANKL and OPG mRNA expression in osteoblastic MC3T3-E1 cells following treatment with conditioned MCF7 medium. Co-cultured MC3T3-E1 and bone marrow cells\ntreated with conditioned medium from irradiated MCF7 cells showed decreased numbers of osteoclasts assessed using TRAP staining. Conditioned medium from control MCF7 cells elevated the RANKL/OPG mRNA ratio in MC3T3-E1 cells; this effect was suppressed by carbon ion irradiation of the MCF7 cells. These data demonstrate that indirect interactions between breast cancer cells and MC3T3-E1 cells induce osteoclastogenesis in vitro through modulation of RANKL expression and that this process is suppressed by carbon ion irradiation.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"H21年度HIMAC共同利用研究成果発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"澤尻, 昌彦"}],"nameIdentifiers":[{"nameIdentifier":"632350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野村, 雄二"}],"nameIdentifiers":[{"nameIdentifier":"632351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝波, 修一"}],"nameIdentifiers":[{"nameIdentifier":"632352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山, 耕一"}],"nameIdentifiers":[{"nameIdentifier":"632353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江, 純悦"}],"nameIdentifiers":[{"nameIdentifier":"632354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"澤尻 昌彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野村 雄二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝波 修一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632357","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山 耕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632358","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江 純悦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632359","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"重粒子線の骨代謝におよぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"重粒子線の骨代謝におよぼす影響"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-11-16"},"publish_date":"2010-11-16","publish_status":"0","recid":"64104","relation_version_is_last":true,"title":["重粒子線の骨代謝におよぼす影響"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:15:23.261883+00:00"}