@misc{oai:repo.qst.go.jp:00064104,
 author = {澤尻, 昌彦 and 野村, 雄二 and 滝波, 修一 and 丸山, 耕一 and 溝江, 純悦 and 澤尻 昌彦 and 野村 雄二 and 滝波 修一 and 丸山 耕一 and 溝江 純悦},
 month = {Apr},
 note = {To examine the effects of carbon ion and gamma ray irradiation on cancer-induced osteoclastogenesis, mouse calvarias MC3T3-E1cells were cultured with conditioned medium from irradiated and non-irradiated MCF7 human breast cancer cells. We examined RANKL and OPG mRNA expression in osteoblastic MC3T3-E1 cells following treatment with conditioned MCF7 medium. Co-cultured MC3T3-E1 and bone marrow cells
treated with conditioned medium from irradiated MCF7 cells showed decreased numbers of osteoclasts assessed using TRAP staining. Conditioned medium from control MCF7 cells elevated the RANKL/OPG mRNA ratio in MC3T3-E1 cells; this effect was suppressed by carbon ion irradiation of the MCF7 cells. These data demonstrate that indirect interactions between breast cancer cells and MC3T3-E1 cells induce osteoclastogenesis in vitro through modulation of RANKL expression and that this process is suppressed by carbon ion irradiation., H21年度HIMAC共同利用研究成果発表会},
 title = {重粒子線の骨代謝におよぼす影響},
 year = {2010}
}