WEKO3
アイテム
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統合失調症における抗精神病薬前後でのドーパミン生成能の変化
https://repo.qst.go.jp/records/64102
https://repo.qst.go.jp/records/641026c2ce086-e54e-4e56-bca2-31c2d60ac9f7
Item type | 会議発表用資料 / Presentation(1) | |||||
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公開日 | 2010-11-16 | |||||
タイトル | ||||||
タイトル | 統合失調症における抗精神病薬前後でのドーパミン生成能の変化 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
高野, 晴成
× 高野, 晴成× 伊藤, 浩× 荒川, 亮介× 高橋, 英彦× 須原, 哲也× 高野 晴成× 伊藤 浩× 荒川 亮介× 高橋 英彦× 須原 哲也 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aim:To evaluate the changes in dopamine (DA) synthesis capacity before and after antipsychotic treatment in patients with schizophrenia. Method:Twelve patients underwent positron emission tomography studies with [11C]DOPA before (baseline) and 1 day after treatment with antipsychotic drug, risperidone. DA synthesis capacity, ki, was determined for the striatum using a graphical plot analysis method and with the occipital cortex as a reference region. Result:Patients showed no significant unidirectional change in DA synthesis capacity before and after risperidone administration; However, a significant negative correlation was observed between the baseline ki value and the change rate of ki before and after risperidone administration (r = -0.63, p = 0.029). Conclusion:These findings might be indicative of a stabilizing effect of risperidone to the presynaptic DA function. |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第50回日本核医学会学術総会 | |||||
発表年月日 | ||||||
日付 | 2010-11-13 | |||||
日付タイプ | Issued |