@misc{oai:repo.qst.go.jp:00064102,
 author = {高野, 晴成 and 伊藤, 浩 and 荒川, 亮介 and 高橋, 英彦 and 須原, 哲也 and 高野 晴成 and 伊藤 浩 and 荒川 亮介 and 高橋 英彦 and 須原 哲也},
 month = {Nov},
 note = {Aim:To evaluate the changes in dopamine (DA) synthesis capacity before and after antipsychotic treatment in patients with schizophrenia.
Method:Twelve patients underwent positron emission tomography studies with [11C]DOPA before (baseline) and 1 day after treatment with antipsychotic drug, risperidone. DA synthesis capacity, ki, was determined for the striatum using a graphical plot analysis method and with the occipital cortex as a reference region.
Result:Patients showed no significant unidirectional change in DA synthesis capacity before and after risperidone administration; However, a significant negative correlation was observed between the baseline ki value and the change rate of ki before and after risperidone administration (r = -0.63, p = 0.029).
Conclusion:These findings might be indicative of a stabilizing effect of risperidone to the presynaptic DA function., 第50回日本核医学会学術総会},
 title = {統合失調症における抗精神病薬前後でのドーパミン生成能の変化},
 year = {2010}
}