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Effects of X-ray irradiation on CD180-negative B cells in SLE-model NEZBWF1 mice
https://repo.qst.go.jp/records/63996
https://repo.qst.go.jp/records/63996595de9cb-724a-47f2-aa70-018ffa91a9df
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-09-14 | |||||
| タイトル | ||||||
| タイトル | Effects of X-ray irradiation on CD180-negative B cells in SLE-model NEZBWF1 mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujita, Kazuko
× Fujita, Kazuko× Bing, Wang× Kuwabara, Taku× Tanaka, Kaoru× Kamata, Itaru× Akasaka, Yoshikiyo× Ishii, Toshiharu× 藤田 和子× 王 冰× 桑原 卓× 田中 薫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | CD180 molecule, a homologue of TLR-4, expresses on mature B cells. CD180-negative B cells in peripheral blood in SLE patients were reported to increase and to reflected the activity of SLE, in addition, they produce autoantibodies in vitro. These results suggest that CD180 expression was strongly associated with autoimmune reaction. We previously showed that CD180-negative spleen B cells exhibited greater radiosensitive than CD180-positive cells. In this study, we examined the radiation effects on CD180-negative B cells using an animal SLE model, the NZBWF1 female mice. After the onset of the early symptoms of protein urea, mice were paired according to the degree of the symptoms and the body weight. One of the pair was irradiated by 4 Gy, and the other sham-irradiated. The mean life span of the irradiated mice was significantly extended compared with that of the sham-irradiated mice and the same results were obtained when comparing with the paired mice. The amount of complement C3 in peripheral blood of the irradiated mice was sustained markedly at higher levels than that of sham-irradiated mice at 3 weeks after irradiation. Immunohistological examination of kidneys showed increased number of CD180-negative B cells after the onset of the early symptom. The findings indicate the possibility that radiation could eliminate effectively CD180-negative B cells, leading to reduction of autoantibody production, and thus relieve SLE symptoms. The findings also suggest the possibility of the effectiveness of practical application of radiotherapy into autoimmune diseases associated with the expression of CD180-negative cells. : |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第14回国際免疫学会議 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-08-27 | |||||
| 日付タイプ | Issued | |||||
