{"created":"2023-05-15T14:46:38.587900+00:00","id":63996,"links":{},"metadata":{"_buckets":{"deposit":"6ad9a9b7-9dfc-42e8-93d9-4f4f648e2504"},"_deposit":{"created_by":1,"id":"63996","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63996"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063996","sets":["10:29"]},"author_link":["631403","631408","631409","631406","631402","631412","631404","631407","631411","631410","631405"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-08-27","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD180 molecule, a homologue of TLR-4, expresses on mature B cells. CD180-negative B cells in peripheral blood in SLE\npatients were reported to increase and to reflected the activity of SLE, in addition, they produce autoantibodies in vitro. These results\nsuggest that CD180 expression was strongly associated with autoimmune reaction. We previously showed that CD180-negative spleen B\ncells exhibited greater radiosensitive than CD180-positive cells. In this study, we examined the radiation effects on CD180-negative B\ncells using an animal SLE model, the NZBWF1 female mice. After the onset of the early symptoms of protein urea, mice were paired\naccording to the degree of the symptoms and the body weight. One of the pair was irradiated by 4 Gy, and the other sham-irradiated.\nThe mean life span of the irradiated mice was significantly extended compared with that of the sham-irradiated mice and the same\nresults were obtained when comparing with the paired mice. The amount of complement C3 in peripheral blood of the irradiated mice\nwas sustained markedly at higher levels than that of sham-irradiated mice at 3 weeks after irradiation. Immunohistological examination\nof kidneys showed increased number of CD180-negative B cells after the onset of the early symptom. The findings indicate the\npossibility that radiation could eliminate effectively CD180-negative B cells, leading to reduction of autoantibody production, and thus\nrelieve SLE symptoms. The findings also suggest the possibility of the effectiveness of practical application of radiotherapy into\nautoimmune diseases associated with the expression of CD180-negative cells.\n:","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第14回国際免疫学会議","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujita, Kazuko"}],"nameIdentifiers":[{"nameIdentifier":"631402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"631403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuwabara, Taku"}],"nameIdentifiers":[{"nameIdentifier":"631404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"631405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamata, Itaru"}],"nameIdentifiers":[{"nameIdentifier":"631406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akasaka, Yoshikiyo"}],"nameIdentifiers":[{"nameIdentifier":"631407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Toshiharu"}],"nameIdentifiers":[{"nameIdentifier":"631408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 和子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"桑原 卓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631412","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Effects of X-ray irradiation on CD180-negative B cells in SLE-model NEZBWF1 mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of X-ray irradiation on CD180-negative B cells in SLE-model NEZBWF1 mice"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-09-14"},"publish_date":"2010-09-14","publish_status":"0","recid":"63996","relation_version_is_last":true,"title":["Effects of X-ray irradiation on CD180-negative B cells in SLE-model NEZBWF1 mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:16:36.409387+00:00"}