@misc{oai:repo.qst.go.jp:00063996,
 author = {Fujita, Kazuko and Bing, Wang and Kuwabara, Taku and Tanaka, Kaoru and Kamata, Itaru and Akasaka, Yoshikiyo and Ishii, Toshiharu and 藤田 和子 and 王 冰 and 桑原 卓 and 田中 薫},
 month = {Aug},
 note = {CD180 molecule, a homologue of TLR-4, expresses on mature B cells. CD180-negative B cells in peripheral blood in SLE
patients were reported to increase and to reflected the activity of SLE, in addition, they produce autoantibodies in vitro. These results
suggest that CD180 expression was strongly associated with autoimmune reaction. We previously showed that CD180-negative spleen B
cells exhibited greater radiosensitive than CD180-positive cells. In this study, we examined the radiation effects on CD180-negative B
cells using an animal SLE model, the NZBWF1 female mice. After the onset of the early symptoms of protein urea, mice were paired
according to the degree of the symptoms and the body weight. One of the pair was irradiated by 4 Gy, and the other sham-irradiated.
The mean life span of the irradiated mice was significantly extended compared with that of the sham-irradiated mice and the same
results were obtained when comparing with the paired mice. The amount of complement C3 in peripheral blood of the irradiated mice
was sustained markedly at higher levels than that of sham-irradiated mice at 3 weeks after irradiation. Immunohistological examination
of kidneys showed increased number of CD180-negative B cells after the onset of the early symptom. The findings indicate the
possibility that radiation could eliminate effectively CD180-negative B cells, leading to reduction of autoantibody production, and thus
relieve SLE symptoms. The findings also suggest the possibility of the effectiveness of practical application of radiotherapy into
autoimmune diseases associated with the expression of CD180-negative cells.
:, 第14回国際免疫学会議},
 title = {Effects of X-ray irradiation on CD180-negative B cells in SLE-model NEZBWF1 mice},
 year = {2010}
}