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Usefulness of methionine PET for response evaluation and predicting prognosis of uterine cervical cancer treated by carbon-ion beam radiotherapy
https://repo.qst.go.jp/records/63654
https://repo.qst.go.jp/records/6365464e424ff-0254-483d-909e-18d0299a6400
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-21 | |||||
| タイトル | ||||||
| タイトル | Usefulness of methionine PET for response evaluation and predicting prognosis of uterine cervical cancer treated by carbon-ion beam radiotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshikawa, Kyosan
× Yoshikawa, Kyosan× Ohashi, Seiya× Toubaru, Sachiko× Hasebe, Mitsuhiko× Ishikawa, Hiroyuki× Sagou, Kenji× Tamura, Katsumi× Tanimoto, Katsuyuki× Kiyohara, Hiroki× Kato, Shingo× Kandatsu, Susumu× Fukumura, Toshimitsu× Saga, Tsuneo× Tsujii, Hirohiko× 吉川 京燦× 大橋 靖也× 桃原 幸子× 長谷部 充彦× 石川 博之× 田村 克巳× 谷本 克之× 清原 浩樹× 加藤 眞吾× 神立 進× 福村 利光× 佐賀 恒夫× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: The carbon-ion beam radiotherapy (CIRT) has been introduced in our institute. We have treated uterine cervical cancer using CIRT and C-11 methionine (MET) PET was performed for assessment of the cervical tumor metabolism before and after CIRT. We evaluated if C-11 methionine (MET) uptake was early predictor for local recurrence, systemic metastasis and prognosis in patients with uterine cervical cancer treated by CIRT. METHODS AND MATERIALS: MET-PET was performed in histologically confirmed 71 patients with uterine cervical cancer before and after CIRT. There were 45 squamous cell carcinoma and 26 adenocarcinoma. ECAT EXACT HR+ and ECAT EXACT 47 PET scanner (Siemens CTI, Knoxville, TN) was used for PET imaging. MET-PET findings were compared with clinical follow-up result up to 152.4 months (mean: 46.1 months). MET uptake was measured with a semi-quantitative index, tumor to normal tissue ratio (TNR). Pre- and post-therapeutic tumor TNR, its change after CIRT, rate of local recurrence, rate of systemic metastasis and prognosis were entered into Kaplan-Meire analysis. RESULTS: All 71 uterine cervical cancers accumulated MET in the PET imaging. The intensity of the uptake of squamous cell carcinoma has a higher tendency than that of adenocarcinoma (mean TNR 10.2 and 8.6, respectively), although there was no significant difference between them. Pre-therapeutic TNR had statistically significant relationship to local recurrence, systemic metastasis and prognosis (cutoff=8.9, 14.7, 12.6 and p=0.038, 0.024, 0.026, respectably). Post-therapeutic TNR significantly related to recurrence and prognosis (cutoff=7.5, 3.8 and p=0.0016, 0.0024, respectably), and TNR residual ratio after CIRT significantly related to metastasis and prognosis (cutoff=60.8%, 60.8% and p=0.0090, 0.0024, respectably). In squamous cell carcinoma group, pre-therapeutic TNR had statistically significant relationship to metastasis and prognosis. In adenocarcinoma group, pre-therapeutic TNR significantly related only to recurrence. CONCLUSIONS: MET-PET was a successful predictor for local recurrence, systemic metastasis and prognosis in patients with uterine cervical cancer treated by CIRT. But the relationship depended on the histological type of cervical cancer. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 2009 EANM Congress | |||||
| 発表年月日 | ||||||
| 日付 | 2009-10-14 | |||||
| 日付タイプ | Issued | |||||
