{"created":"2023-05-15T14:46:23.005377+00:00","id":63654,"links":{},"metadata":{"_buckets":{"deposit":"e3110c5f-7b29-40ee-b944-6020b70196a9"},"_deposit":{"created_by":1,"id":"63654","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63654"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063654","sets":["10:29"]},"author_link":["628272","628246","628252","628263","628247","628249","628259","628254","628269","628268","628255","628261","628260","628248","628265","628256","628251","628250","628270","628266","628262","628258","628257","628264","628267","628271","628253"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-14","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE: The carbon-ion beam radiotherapy (CIRT) has been introduced in our institute. We have treated uterine cervical cancer using CIRT and C-11 methionine (MET) PET was performed for assessment of the cervical tumor metabolism before and after CIRT. We evaluated if C-11 methionine (MET) uptake was early predictor for local recurrence, systemic metastasis and prognosis in patients with uterine cervical cancer treated by CIRT. METHODS AND MATERIALS: MET-PET was performed in histologically confirmed 71 patients with uterine cervical cancer before and after CIRT. There were 45 squamous cell carcinoma and 26 adenocarcinoma. ECAT EXACT HR+ and ECAT EXACT 47 PET scanner (Siemens CTI, Knoxville, TN) was used for PET imaging. MET-PET findings were compared with clinical follow-up result up to 152.4 months (mean: 46.1 months). MET uptake was measured with a semi-quantitative index, tumor to normal tissue ratio (TNR). Pre- and post-therapeutic tumor TNR, its change after CIRT, rate of local recurrence, rate of systemic metastasis and prognosis were entered into Kaplan-Meire analysis. RESULTS: All 71 uterine cervical cancers accumulated MET in the PET imaging. The intensity of the uptake of squamous cell carcinoma has a higher tendency than that of adenocarcinoma (mean TNR 10.2 and 8.6, respectively), although there was no significant difference between them. Pre-therapeutic TNR had statistically significant relationship to local recurrence, systemic metastasis and prognosis (cutoff=8.9, 14.7, 12.6 and p=0.038, 0.024, 0.026, respectably). Post-therapeutic TNR significantly related to recurrence and prognosis (cutoff=7.5, 3.8 and p=0.0016, 0.0024, respectably), and TNR residual ratio after CIRT significantly related to metastasis and prognosis (cutoff=60.8%, 60.8% and p=0.0090, 0.0024, respectably). In squamous cell carcinoma group, pre-therapeutic TNR had statistically significant relationship to metastasis and prognosis. In adenocarcinoma group, pre-therapeutic TNR significantly related only to recurrence. CONCLUSIONS: MET-PET was a successful predictor for local recurrence, systemic metastasis and prognosis in patients with uterine cervical cancer treated by CIRT. But the relationship depended on the histological type of cervical cancer.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 2009 EANM Congress","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshikawa, Kyosan"}],"nameIdentifiers":[{"nameIdentifier":"628246","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohashi, Seiya"}],"nameIdentifiers":[{"nameIdentifier":"628247","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toubaru, Sachiko"}],"nameIdentifiers":[{"nameIdentifier":"628248","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasebe, Mitsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"628249","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"628250","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sagou, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"628251","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamura, Katsumi"}],"nameIdentifiers":[{"nameIdentifier":"628252","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanimoto, Katsuyuki"}],"nameIdentifiers":[{"nameIdentifier":"628253","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiyohara, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"628254","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Shingo"}],"nameIdentifiers":[{"nameIdentifier":"628255","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kandatsu, Susumu"}],"nameIdentifiers":[{"nameIdentifier":"628256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumura, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"628257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"628258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"628259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉川 京燦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大橋 靖也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"桃原 幸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷部 充彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 博之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田村 克巳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷本 克之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清原 浩樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 眞吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神立 進","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628272","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Usefulness of methionine PET for response evaluation and predicting prognosis of uterine cervical cancer treated by carbon-ion beam radiotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Usefulness of methionine PET for response evaluation and predicting prognosis of uterine cervical cancer treated by carbon-ion beam radiotherapy"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-21"},"publish_date":"2009-10-21","publish_status":"0","recid":"63654","relation_version_is_last":true,"title":["Usefulness of methionine PET for response evaluation and predicting prognosis of uterine cervical cancer treated by carbon-ion beam radiotherapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:20:31.380642+00:00"}