@misc{oai:repo.qst.go.jp:00063654,
 author = {Yoshikawa, Kyosan and Ohashi, Seiya and Toubaru, Sachiko and Hasebe, Mitsuhiko and Ishikawa, Hiroyuki and Sagou, Kenji and Tamura, Katsumi and Tanimoto, Katsuyuki and Kiyohara, Hiroki and Kato, Shingo and Kandatsu, Susumu and Fukumura, Toshimitsu and Saga, Tsuneo and Tsujii, Hirohiko and 吉川 京燦 and 大橋 靖也 and 桃原 幸子 and 長谷部 充彦 and 石川 博之 and 田村 克巳 and 谷本 克之 and 清原 浩樹 and 加藤 眞吾 and 神立 進 and 福村 利光 and 佐賀 恒夫 and 辻井 博彦},
 month = {Oct},
 note = {PURPOSE: The carbon-ion beam radiotherapy (CIRT) has been introduced in our institute. We have treated uterine cervical cancer using CIRT and C-11 methionine (MET) PET was performed for assessment of the cervical tumor metabolism before and after CIRT. We evaluated if C-11 methionine (MET) uptake was early predictor for local recurrence, systemic metastasis and prognosis in patients with uterine cervical cancer treated by CIRT. METHODS AND MATERIALS: MET-PET was performed in histologically confirmed 71 patients with uterine cervical cancer before and after CIRT. There were 45 squamous cell carcinoma and 26 adenocarcinoma. ECAT EXACT HR+ and ECAT EXACT 47 PET scanner (Siemens CTI, Knoxville, TN) was used for PET imaging. MET-PET findings were compared with clinical follow-up result up to 152.4 months (mean: 46.1 months). MET uptake was measured with a semi-quantitative index, tumor to normal tissue ratio (TNR). Pre- and post-therapeutic tumor TNR, its change after CIRT, rate of local recurrence, rate of systemic metastasis and prognosis were entered into Kaplan-Meire analysis. RESULTS: All 71 uterine cervical cancers accumulated MET in the PET imaging. The intensity of the uptake of squamous cell carcinoma has a higher tendency than that of adenocarcinoma (mean TNR 10.2 and 8.6, respectively), although there was no significant difference between them. Pre-therapeutic TNR had statistically significant relationship to local recurrence, systemic metastasis and prognosis (cutoff=8.9, 14.7, 12.6 and p=0.038, 0.024, 0.026, respectably). Post-therapeutic TNR significantly related to recurrence and prognosis (cutoff=7.5, 3.8 and p=0.0016, 0.0024, respectably), and TNR residual ratio after CIRT significantly related to metastasis and prognosis (cutoff=60.8%, 60.8% and p=0.0090, 0.0024, respectably). In squamous cell carcinoma group, pre-therapeutic TNR had statistically significant relationship to metastasis and prognosis. In adenocarcinoma group, pre-therapeutic TNR significantly related only to recurrence. CONCLUSIONS: MET-PET was a successful predictor for local recurrence, systemic metastasis and prognosis in patients with uterine cervical cancer treated by CIRT. But the relationship depended on the histological type of cervical cancer., The 2009 EANM Congress},
 title = {Usefulness of methionine PET for response evaluation and predicting prognosis of uterine cervical cancer treated by carbon-ion beam radiotherapy},
 year = {2009}
}