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メダカモデル：生体内がん細胞動態の直接観察
https://repo.qst.go.jp/records/63633
https://repo.qst.go.jp/records/63633ef2fc567-b85a-498b-a5f9-24445dcadc03
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-07 | |||||
| タイトル | ||||||
| タイトル | メダカモデル：生体内がん細胞動態の直接観察 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
長谷川, 純崇
× 長谷川, 純崇× 古川, 高子× 佐賀, 恒夫× 長谷川 純崇× 古川 高子× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The recent success with small fish as an animal model of cancer has attracted cancer researchers'attention because of the capability of directly visualizing tumor cells in vivo. Here we report a unique medaka model, in which we are able to observe various cell behaviors of in vivo transplanted tumor cells such as cell proliferation and metastasis. We established medaka melanoma (MM) cells stably expressing green fluorescence protein (GFP) and transplanted them into non-irradiated and irradiated medaka. The tumor cells were grown at the injection sites in medaka, and the spatiotemporal changes were visualized under fluorescence stereoscopic microscope with a cellular level-resolution, even at a single cell level. Tumor dormancy and metastasis were also observed. Interestingly, in irradiated medaka, accelerated tumor growth and metastasis of the transplanted tumor cells were directly visualized. Our medaka model provides a new opportunity to visualize in vivo tumor cells"as seen in a culture dish" |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第68回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-10-03 | |||||
| 日付タイプ | Issued | |||||
